Table 3 Associations of TM6SF2 rs58542926 with health utilization and hospitalization (n = 3759)

Model 1 (age, sex, school education, income, alcohol intake, smoking status, eGFR)

 CT

+53.04 (+18.33, +115.29)*

1.93 (0.67, 5.03)

+85.33 (+18.94, +188.78)*

 TT

+67.56 (+28.28, +134.59)*

1.81 (0.59, 5.08)

+123.74 (+33.14, +275.97)*

Model 2: model 1 + Functional Comorbidity Index

 CT

+57.82 (+23.62, +113.43)*

1.96 (0.68, 5.56)

+94.01 (37.83, 173.1)*

 TT

+69.79 (+31.60, 145.43)*

1.82 (0.72, 5.75)

+133.49 (51.86, 259.0)*

Model 3: Model 2 + hepatic steatosis

 CT

+56.54 (+15.03, +110.21)*

1.93 (0.78, 5.44)

+93.36 (+35.99, +174.93)*

 TT

+69.28 (+24.58, +130.01)*

1.80 (0.68, 5.10)

+132.83 (+51.83, +257.1)*

Model 4: Model 2 + ALT

 CT

+56.51 (+19.96, +112.33)*

1.91 (0.65, 4.98)

+91.50 (+40.32, +161.36)*

 TT

+69.65 (+31.38, 136.92)*

1.79 (0.63, 5.04)

+131.08 (+53.60, 247.63)*

Model 5: Model 2 + ferritin

 CT

+55.75 (+21.37, +106.99)*

1.83 (0.63, 5.38)

+94.00 (+37.65, +173.43)*

 TT

+69.09 (+31.92, +134.08)*

1.73 (0.56, 4.98)

+133.47 (+52.00, +259.61)*

Model 6: Model 1 + metabolic syndrome

 CT

+45.21 (+7.26, +107.45)**

1.81 (0.65, 5.34)

+74.58 (+13.38, +168.79)**

 TT

+60.48 (+14.54, 124.9)*

1.73 (0.68, 5.63)

+114.92 (+30.05, +255.17)*

Model 7: Model 1 + waist circumference

 CT

+49.27 (7.63, +95.57)*

1.92 (0.80, 5.12)

+90.50 (+32.88, +73.10)*

 TT

+63.27 (+23.38, +138.34)*

1.79 (0.70, 4.71)

+131.9 (+47.56, 264.6)*

Model 8: Model 1 + BMI

 CT

+50.28 (+12.46, 106.67)*

1.92 (0.58, 5.49)

+92.70 (+27.32, 191.65)*

 TT

+64.73 (+23.39, +119.28)*

1.80 (0.55, 5.21)

+133.3 (+41.87, 283.35)*

Model 9: Model 1 + triglycerides

 CT

+50.08 (+15.38, +195.16)*

1.89 (0.68, 5.61)

+83.47 (+16.35, +189.29)*

 TT

+65.92 (+23.72, +120.61)*

1.79 (0.62, 5.14)

+119.17 (+29.87, 269.89)*

Model 10: Model 1 + HDL cholesterol

 CT

+50.69 (+15.98, +238.0)*

1.89 (0.69, 5.14)

+77.12 (+11.73, +180.78)**

 TT

+66.26 (+26.23, +158.59)*

1.75 (0.64, 5.04)

+116.1 (+27.42, +266.50)*

Model 11: Model 1 + systolic blood pressure

 CT

+53.16 (+22.27, +141.1)*

1.93 (0.60, 5.09)

+84.63 (+18.88, +186.75)*

 TT

+66.64 (+30.17, 167.93)*

1.77 (0.51, 4.73)

+124.11 (+33.36, +276.62)*

Model 12: Model 1 + serum glucose

 CT

+50.51 (+13.57, +105.38)*

1.91 (0.64, 5.50)

+82.57 (+17.68, 183.2)*

 TT

+63.36 (+21.72, 116.9)*

1.81 (0.58, 5.47)

+121.82 (+32.44, 271.50)*

Model 13: Model 1 + hbA1c

 CT

+53.38 (+21.00, +109.69)*

1.94 (0.82, 5.74)

+85.09 (+18.75, +188.49)*

 TT

+67.02 (+29.44, 23.17)*

1.82 (0.72, 5.52)

+122.18 (+32.83, 275.01)*