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Table 2 Associations of PNPLA3 rs738409 with health utilization and hospitalization (n = 3759)

From: Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study

Reference: PNPLA3 rs738409 CC Effect on annual outpatient visits, % Bootstrap (95 %-CI)a Hospitalization, OR Bootstrap (95 %-CI) Effect on annual inpatient days, % Bootstrap (95 %-CI)a
Model 1 (age, sex, school education, income, alcohol intake, smoking status, GFR)    
 CG −3.17 (−9.00, +4.08) 1.01 (0.83, 1.21) −9.00 (−25.12, +7.10)
 GG +2.93 (−12.9, +21.7) 1.51 (1.02, 2.15)* +7.38 (−22.45, +42.87)
Model 2: model 1 + Functional Comorbidity Index    
 CG −2.43 (−8.5, +3.5) 1.03 (0.89, 1.23) −10.31 (−23.1, +10.44)
 GG +1.81 (−11.62, +18.29) 1.51 (1.01, 2.28)* +7.49 (−21.24, +48.61)
Model 3: Model 2 + hepatic steatosis    
 CG −2.64 (−8.89, +2.65) 1.03 (0.83, 1.23) −11.30 (−26.33, +8.15)
 GG +1.98 (−9.49, +19.92) 1.54 (1.03, 2.17)* +7.51 (−23.45, +59.25)
Model 4: Model 2 + ALT    
 CG −2.33 (−8.82, +4.83) 1.04 (0.85, 1.26) −9.90 (−23.65, +3.81)
 GG +2.84 (−9.20, +21.91) 1.56 (1.02, 2.27)* +8.80 (−22.86, 50.62)
Model 5: Model 2 + ferritin    
 CG −2.41 (−7.74, +5.52) 1.02 (0.85, 1.20) −11.3 (−25.02, +7.89)
 GG +1.57 (−12.67, +25.28) 1.49 (1.01, 2.35)* +7.42 (−67.07, +49.20)
Model 6: Model 1 + metabolic syndrome    
 CG −2.45 (−8.97, +4.41) 1.03 (0.84, 1.31) −9.73 (−24.1, +10.60)
 GG +4.13 (−9.85, +24.94) 1.53 (1.02, 2.28)* +6.23 (−24.49, +40.60)
Model 7: Model 1 + waist circumference    
 CG −2.48 (−9.04, +4.56) 1.02 (0.84, 1.23) −9.34 (−25.14, +7.67)
 GG +4.18 (−9.17, +20.31) 1.51 (1.02, 2.26)* +7.29 (−22.41, +50.45)
Model 8: Model 1 + BMI    
 CG −2.74 (−8.65, +4.67) 1.02 (0.85, 1.22) −9.44 (−23.11, +8.88)
 GG +3.31 (−14.11, +20.54) 1.51 (0.99, 2.23)* +6.75 (−28.51, +43.60)
Model 9: Model 1 + triglycerides    
 PNPLA3    
 CG −2.70 (−8.43, +5.48) 1.02 (0.87, 1.31) −7.83 (−23.36, +10.71)
 GG +3.16 (−11.65, +23.22) 1.51 (1.01, 2.21)* +7.02 (+22.9, +58.96)
Model 10: Model 1 + HDL cholesterol    
 CG −2.83 (−9.55, +3.89) 1.005 (0.83, 1.25) −9.52 (−23.12, +7.25)
 GG +3.24 (−7.22, +23.89) 1.52 (1.02, 2.22)* +7.97 (−27.34, +44.13)
Model 11: Model 1 + systolic blood pressure    
 CG −2.69 (−8.49, +3.44) 1.02 (0.85, 1.24) −9.03 (+26.12, +10.44)
 GG +3.44 (−14.57, +19.68) 1.52 (1.03, 2.32)* +7.02 (−22.73, +43.84)
Model 12: Model 1 + serum glucose    
 CG −2.92 (−9.10, +4.59) 1.02 (0.83, 1.22) −9.59 (−24.54, +12.97)
 GG +3.30 (+11.4, +23.1) 1.49 (1.02, 2.24)* +6.06 (−24.05, 43.55)
Model 13: Model 1 + hbA1c    
 CG −3.32 (−9.67, +4.24) 1.02 (0.83, 1.22) −9.20 (−23.78, +7.61)
 GG +4.44 (−11.01, +26.81) 1.52 (0.96, 2.05)* +7.79 (−21.70, +41.90)
  1. Model 1 included age, sex, school education, income, alcohol intake, smoking status, eGFR
  2. Bias-corrected Bootstrap confidence intervals
  3. CI confidence interval
  4. aPercent change compared to the ‘CC-genotype’ group
  5. *p -value < 0.05