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Table 4 Results of one-way sensitivity analysis

From: Ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Greece: a cost-utility study

Input parameter

Base case value

aLow value

ICER

aHigh value

ICER

Cost of ranolazine

€268

€214

€3511

€322

€5725

Cost of SoC

€159

€127

€4598

€191

€4643

Cost of hospitalization with no revas (mid, minimal, moderate)

€340

€272

€4692

€408

€4549

Cost of hospitalization with no revas (severe)

€865

€692

€4438

€1038

€4803

Cost of hospitalization with CABG

€5772

€4617

€4841

€6926

€4611

Cost of hospitalization with PCI/Stent

€1797

€1438

€4712

€2157

€4528

Probability of patients continuing on Ranolazine therapy

0.72

0.576

€7539

0.864

€2675

Probability of hospitalization with minimal angina

0.20

0.16

€4570

0.24

€4671

Probability of hospitalization with mild angina

0.20

0.16

€3858

0.24

€5393

Probability of hospitalization with moderate angina

0.27

0.21

€5572

0.31

€3684

Probability of hospitalization with severe angina

0.30

0.24

€5497

0.36

€3747

Utility for no hospitalization (minimal angina)

0.81

0.65

€4842

0.97

€4418

Utility for no hospitalization (mild angina)

0.75

0.60

€10,076

0.90

€2938

Utility for no hospitalization (moderate angina)

0.60

0.48

€3369

0.72

€7349

Utility for no hospitalization (severe angina)

0.39

0.31

€4391

0.47

€4875

Utility for hospitalization without revas (minimal angina)

0.80

0.64

€4647

0.96

€4594

Utility for hospitalization without revas (mild angina)

0.74

0.59

€4976

0.89

€4312

Utility for hospitalization without revas (moderate angina)

0.59

0.47

€4335

0.71

€4946

Utility for hospitalization without revas (severe angina)

0.38

0.30

€4572

0.46

€4670

Utility for hospitalization with revas (minimal angina )

0.75

0.60

€4645

0.90

€4596

Utility for hospitalization with revas (mild angina)

0.69

0.55

€4955

0.83

€4328

Utility for hospitalization with revas (moderate angina)

0.54

0.43

€4353

0.65

€4922

Utility for hospitalization with revas (severe angina)

0.33

0.26

€4576

0.40

€4666

  1. SoC: standard of care, CABG: coronary artery bypass graft, PCI/STENT: percutaneous transluminal angioplasty& stenting, Revas: revascularization
  2. aLow and high values currently based on ± 20 % variation from the base case
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