Actions following adverse drug events – how do these influence uptake and utilisation of newer and/or similar medications?

Table 2 Timeline of relevant activities potentially influencing utilisation of bisphosphonates in Australia (for further detail, see Peeters et al. [10])

2001	PBS	Alendronate, risendronate, etidronate available for post-menopausal women with established osteoporosis with minimal trauma fracture
2004	ADRAC	Reports of eye-problems related to bisphosphonates
2006	ADRAC	Reports of osteonecrosis of the jaw related to bisphosphonates
2007	PBS	Bisphosphonates, also includes women > 70years with BMD T score < −3.0
	ADRAC	Reports of renal impairment related to bisphosphonates, particularly zolendronic acid. Further reports of osteonecrosis of the jaw related to bisphosphonates
	Media	ABC television - The 7.30 Report on osteonecrosis of the jaw related to alendronate
	TGA	Safety Alert -advice issued December 2007 about bisphosphonate drugs and osteonecrosis of the jaw
2008	PBS	Zoledronic acid for patients with vertebral fracture
2009	PBS	Zolendronic acid, also includes women > 70years with BMD T score < −3.0

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