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Table 1 Characteristics of included RCT studies in the Cochrane meta-analysis of adverse mortality effects Aprotinin versus placebo.

From: The aprotinin saga and the risks of conducting meta-analyses on small randomised controlled trials – a critique of a Cochrane review

Reference, author Adverse-mortality effects formulated as an outcome in the objective Included patients [N] and design or power to analyse adverse mortality effects
N
Method and follow-up period for studying adverse mortality effects
Alvarez, 1995 No 100 No Not specified
Bidstrup, 1989 No 80 No Not specified
Bidstrup, 1993 No 90 No Not specified, 7–12 days
Blauhut, 1994 No 43 No Not specified
Casas, 1995 No 149 No Not specified
Cosgrove, 1992 No 169 No Not specified
D'Ambra, 1996 Yes 212 No Yes, hospitalisation
Dietrich, 1992 Yes, but no RCT 1784 Yes Yes, hospitalization
Dietrich, 1995 No 30 No Not stated, at least 41 days
Ehrlich, 1998 No 50 No Not stated, at least 30 days
Garcia-Huete, 1997 No 80 No Not stated, at least 30 days
Green, 1995 Yes 84 No Yes, 3 months after discharge.
Hardy, 1993 No 41 No Not specified
Hayashida, 1997 Yes 167 No Not stated, at least 12 days
Jamieson, 1997 No 91 No Not specified
Lab, 1995 No 110 No Yes, hospitalisation
Lemmer, 1996 Yes 704 No Not stated
Lemmer, 1994 Yes 216 No Yes, 30 days mortality
Levy, 1995 Yes 287 No Not specified
Liu, 1993 No 40 No Not specified
Maccario, 1994 [It] No 99 No Not stated
Mohr, 1992 No 50 No Not specified
Okita, 1996 No 112 No Not specified
Rocha, 1994 No 109 No Yes, first 10 days
Royston, 1987 No 22 No Not specified
Stammers, 1997 No 20 No Yes, hospitalisation
Swart, 1994 Yes 100 No Yes, 7 days after surgery
Ashrat, 1997 No 38 No Not stated
Alderman, 1998 No 870 No Yes, hospitalisation
Bidstrup, 2000 No 60 No Not specified, 15 days reported
Cohen, 1998 Yes, maybe 115 No Not specified
Misfeld, 1998 No 42 No Not specified, hospitalisation
Nuttall, 2000 No 168 No Not specified, 24 hours
Schweizer, 2000 No 57 No Not specified
Moran, 2000 No 42 No Yes, 3 months
Murkin, 2000 No 298 No Yes, 3 months
Alvarez, 2001 No 55 No Not specified
Dignan, 2001 No 202 No Not specified
Findlay, 2001 No 63 No Yes, hospitalisation
Kyriss, 2001 No 38 No Not specified
Golanski, 2000 No 54 No Not specified
Palmer, 2003 No 100 No Yes, 3 months
Englberger, 2002a No 29 No Yes, hospitalisation
Englberger, 2002b No 47 No Yes, hospitalisation
Kipfer, 2003 No 30 No Not specified
Rodrigus, 1996 No 93 No Not specified
Kuepper, 2003 No 120 No Yes, 24 hours after surgery
Van der Linden, 2005 No 75 No Probably 30 days
Kunt, 2005 No 86 No Probably 1 day, operative deaths
Koster, 2004 No 200 No Yes, during hospitalisation
Diprose, 2005 No 198 No Not stated
Kuitunen, 2005 No 60 No Not stated
  1. Footnote: The complete references can be found in the Cochrane review by Henry DA et al.[2].