Table 1 Characteristics of included RCT studies in the Cochrane meta-analysis of adverse mortality effects Aprotinin versus placebo.
Reference, author | Adverse-mortality effects formulated as an outcome in the objective | Included patients [N] and design or power to analyse adverse mortality effects N | Method and follow-up period for studying adverse mortality effects | |
|---|---|---|---|---|
Alvarez, 1995 | No | 100 | No | Not specified |
Bidstrup, 1989 | No | 80 | No | Not specified |
Bidstrup, 1993 | No | 90 | No | Not specified, 7–12 days |
Blauhut, 1994 | No | 43 | No | Not specified |
Casas, 1995 | No | 149 | No | Not specified |
Cosgrove, 1992 | No | 169 | No | Not specified |
D'Ambra, 1996 | Yes | 212 | No | Yes, hospitalisation |
Dietrich, 1992 | Yes, but no RCT | 1784 | Yes | Yes, hospitalization |
Dietrich, 1995 | No | 30 | No | Not stated, at least 41 days |
Ehrlich, 1998 | No | 50 | No | Not stated, at least 30 days |
Garcia-Huete, 1997 | No | 80 | No | Not stated, at least 30 days |
Green, 1995 | Yes | 84 | No | Yes, 3 months after discharge. |
Hardy, 1993 | No | 41 | No | Not specified |
Hayashida, 1997 | Yes | 167 | No | Not stated, at least 12 days |
Jamieson, 1997 | No | 91 | No | Not specified |
Lab, 1995 | No | 110 | No | Yes, hospitalisation |
Lemmer, 1996 | Yes | 704 | No | Not stated |
Lemmer, 1994 | Yes | 216 | No | Yes, 30 days mortality |
Levy, 1995 | Yes | 287 | No | Not specified |
Liu, 1993 | No | 40 | No | Not specified |
Maccario, 1994 [It] | No | 99 | No | Not stated |
Mohr, 1992 | No | 50 | No | Not specified |
Okita, 1996 | No | 112 | No | Not specified |
Rocha, 1994 | No | 109 | No | Yes, first 10 days |
Royston, 1987 | No | 22 | No | Not specified |
Stammers, 1997 | No | 20 | No | Yes, hospitalisation |
Swart, 1994 | Yes | 100 | No | Yes, 7 days after surgery |
Ashrat, 1997 | No | 38 | No | Not stated |
Alderman, 1998 | No | 870 | No | Yes, hospitalisation |
Bidstrup, 2000 | No | 60 | No | Not specified, 15 days reported |
Cohen, 1998 | Yes, maybe | 115 | No | Not specified |
Misfeld, 1998 | No | 42 | No | Not specified, hospitalisation |
Nuttall, 2000 | No | 168 | No | Not specified, 24 hours |
Schweizer, 2000 | No | 57 | No | Not specified |
Moran, 2000 | No | 42 | No | Yes, 3 months |
Murkin, 2000 | No | 298 | No | Yes, 3 months |
Alvarez, 2001 | No | 55 | No | Not specified |
Dignan, 2001 | No | 202 | No | Not specified |
Findlay, 2001 | No | 63 | No | Yes, hospitalisation |
Kyriss, 2001 | No | 38 | No | Not specified |
Golanski, 2000 | No | 54 | No | Not specified |
Palmer, 2003 | No | 100 | No | Yes, 3 months |
Englberger, 2002a | No | 29 | No | Yes, hospitalisation |
Englberger, 2002b | No | 47 | No | Yes, hospitalisation |
Kipfer, 2003 | No | 30 | No | Not specified |
Rodrigus, 1996 | No | 93 | No | Not specified |
Kuepper, 2003 | No | 120 | No | Yes, 24 hours after surgery |
Van der Linden, 2005 | No | 75 | No | Probably 30 days |
Kunt, 2005 | No | 86 | No | Probably 1 day, operative deaths |
Koster, 2004 | No | 200 | No | Yes, during hospitalisation |
Diprose, 2005 | No | 198 | No | Not stated |
Kuitunen, 2005 | No | 60 | No | Not stated |