Patient risk profiles and practice variation in nonadherence to antidepressants, antihypertensives and oral hypoglycemics

Liset van Dijk; Eibert R Heerdink; Dinesh Somai; Sandra van Dulmen; Emmy M Sluijs; Denise T de Ridder; Anna MGF Griens; Jozien M Bensing

doi:10.1186/1472-6963-7-51

BMC Health Services Research

Table 2 Nonadherence in antihypertensive use: results of the binomial multilevel analyses on early dropouts and continuers and on refill nonadherence

From: Patient risk profiles and practice variation in nonadherence to antidepressants, antihypertensives and oral hypoglycemics

	Early dropout (0 = continuer; 1 = early dropout)		Refill adherence (0 = adherent > 80%; 1 = nonadherent)
	Odds ratio^a)	95% CI	Odds ratio^a)	95% CI
Socio-demographic characteristics
- age (mean; SD)	0.95*	[0.95–0.96]	1.00	[0.99–1.00]
- % woman	1.29*	[1.09–1.54]	1.08	[0.95–1.23]
- % college/university	1.34*	[1.06–1.69]	1.04	[0.85–1.27]
- % non-western	2.22*	[1.53–3.24]	1.44	[0.97–2.15]
- % private insurance	1.12	[0.93–1.35]	1.09	[0.95–1.25]
- % living together	0.94	[0.71–5.17]	0.88	[0.77–1.02]
- % with job/study	1.08	[0.88–1.32]	1.07	[0.89–1.27]
Medication
Antihypertensives
- % users of beta blockers	0.59*	[0.49–0.72]	0.50*	[0.44–0.57]
- % users of diuretics	ref.		reference
- % users of ace-inhibitors/A2 antagonists	0.25*	[0.17–0.36]	0.37*	[0.31–0.45]
- % users of other antihypertensives	0.58*	[0.43–0.78]	0.30*	[0.23–0.38]
Complex regime
number of other ATCs (mean;sd)	0.94*	[0.92–0.96]	0.97*	[0.96–0.99]
Health & morbidity in general practice
Self-reported health
% excellent/good	1.51*	[1.27–1.81]	0.93	[0.82–1.05]
Diagnoses for which GP is consulted (% of patients)
Diabetes (T90)	0.46*	[0.33–0.65]	0.69*	[0.60–0.91]
Hypertension (K85–K87)	0.11*	[0.08–0.13]	0.77*	[0.64–0.78]
Other diagnoses in K-chapter (from K70–K99)	0.76*	[0.62–0.78]	1.08	[0.98–1.24]
Hypercholesterolemia (T93)	0.50*	[0.32–0.78]	0.88	[0.94–1.10]
GP consultation for chronic diseases and overall contact
Number of other chronic complaints (mean, SD)	1.11*	[1.02–1.21]	1.04	[0.98–1.11]
Number of contacts with GP (mean; SD)	1.04*	[1.03–1.05]	1.02*	[1.01–1.03]
Total (%)
Number of patients (N)	14,219		12,110

* P < 0.05
a) odds ratio > 1: more likely to be an early dropout; odds ratio < 1: less likely to be an early dropout

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