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Table 2 Operating characteristics of diagnostic coding algorithms for the identification of acetaminophen overdose

From: Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data

     

C-statistic (95% CI)

Diagnostic Algorithm

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

All years

1994–2001 (ICD-9-CM era)

2002–2004 (ICD-10 era)

All ICD-9-CM and ICD-10 codes *

100% (97–100%)(139/139)

0% (0–8%)(0/42)

77% (70–83%)(139/181)

0% (0/0)

--

--

--

Principal codes (965.4, T39.1)

90% (84–94%) (125/139)

83% (69–93%) (35/42)

95% (89–98%) (125/132)

71% (57–83%) (35/49)

0.87 (0.80–0.93) ‡

0.86 (0.78–0.94) ‡

0.88 (0.78–0.97)

Specific codes (965.4, T39.1, E850.4, E935.4, Y45.5) †

96% (91–98%) (133/139)

55% (39–70%) (23/42)

88% (81–92%) (133/152)

79% (60–92%) (23/29)

0.75 (0.67–0.83)

0.71 (0.61–0.81)

0.81 (0.69–0.94)

  1. * See Table 1.
  2. † Non-specific codes (ie potentially including overdoses due to medications other than acetaminophen) excluded.
  3. ‡ P < 0.005 vs. the algorithm limited to specific codes.
  4. CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.
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BMC Health Services Research

ISSN: 1472-6963

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