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Table 7 Reporting in guidelines of trials of antihypertensive medication a

From: Methods underpinning national clinical guidelines for hypertension: describing the evidence shortfall

Triala

Yearb

CMA 1999

WHO 1999

VHA 1999

SIGN 2001

ESH 2003

ICSI 2003

JNC 2003

SA 2003

BHS 2004

NICE 2004

VA-II[48]

1970

SR[49, 50]

SR[49,51]

 

SR[49,51,52]

SR[51]

 

SR[53]

SR[51]

SR[49]

✓

HSCSG[54]

1974

SR[50]

SR[51]

 

SR[51]

SR[51]

 

SR[53]

SR[51]

 

✓

USPHS[55]

1977

SR[50]

SR[51]

 

SR[51]

SR[51]

 

SR[53]

SR[51]

 

✓

VA-NHLBI[56]

1978

SR[50]

SR[51]

 

SR[51]

SR[51]

 

SR[53]

SR[51]

 

✓

HDFP[57-59]

1979

SR[49]

SR[49,51]

 

SR[49,51,52,60]

SR[51,61]

✓

✓

SR[51]

SR[49]

✓

ANBPS[62]

1980

 

SR[51]

 

SR[51,52,60]

SR[51,63]

 

SR

SR[51]

 

✓

EWPHE[64,65]

1985

SR[49,50]

SR[49,51,66]

 

✓

SR[51,61]

 

SR[53]

SR[51]

SR[49]

✓

IPPPSH[67]

1985

 

✓

  

✓

    

✓

MRC[68]

1985

SR[50]

✓

 

SR[51]

✓

 

SR[53]

SR[51]

 

✓

Coope[69]

1986

SR[49]

SR[49,51,66]

 

✓

SR[51,61]

 

SR[53]

SR[51]

SR[49]

✓

OSLO[70]

1986

SR[50]

SR[51]

 

SR[51]

SR[51]

 

SR[53]

SR[51]

 

✓

SHEP-P[71-73]

1986

SR[50]

  

SR[60]

SR[61]

 

SR[53]

  

✓

HAPPHY[74]

1987

SR[50]

✓

       

✓

MAPHY[75]

1988

         

✓

CAPPP[76,77]

1990

 

✓

 

✓

✓

  

✓

✓

✓

SHEP[78-81]

1991

✓

✓

 

✓

 

✓

✓

 

✓

✓

STOP-H[82]

1991

SR[49]

✓

 

✓

SR[61]

✓

SR[53]

 

SR[49]

✓

SYST-EUR[83-86]

1991

✓

✓

 

✓

SR[87]

✓

  

✓

✓

MRC-O[88]

1992

SR[50]

✓

 

✓

SR[61]

✓

SR[53]

 

SR[49]

✓

STOP-H2[89-91]

1993

SR[92]

  

✓

SR[63,87,93]

✓

  

✓

✓

NICS-EH[94,95]

1994

SR[92]

   

SR[63,87,93]

   

SR[63,96]

✓

HOT[97]

1995

✓

✓

✓

✓

✓

✓

✓

 

✓

✓

PATS[98]

1995

      

✓

  

✓

ALLHAT[99,100]

1996

    

✓

✓

✓

 

✓

✓

MIDAS[101,102]

1996

SR[50,92]

   

✓

✓

  

SR[63]

✓

VHAS[103]

1997

SR[50,92]

✓

  

SR[3,87,93]

   

SR[63,96]

✓

ABCD[104]

1998

SR[92]

   

SR[87]

✓

✓

 

✓

✓

FACET[105]

1998

SR[92]

        

✓

UKPDS[106]

1998

 

✓

 

✓

✓

✓

✓

✓

✓

✓

HOPE[107]

2000

✓

✓

✓

✓

✓

✓

✓

   

INSIGHT[108,109]

2000

SR[92]

   

✓

   

✓

✓

NORDIL[110]

2000

SR[92]

   

✓

   

✓

✓

IDNT[111]

2001

    

SR[93]

   

SR[96]

✓

PROGRESS[112]

2001

 

✓

 

✓

✓

 

✓

✓

✓

✓

RENAAL[113]

2001

        

✓

✓

ELSA[114]

2002

   

SR[93]

   

SR[96]

  

LIFE[115]

2002

    

✓

 

✓

 

✓

✓

ANBP2[116,117]

2003

    

SR[93]

 

✓

 

SR[96]

✓

CONVINCE[118,119]

2003

    

✓

 

✓

 

SR[96]

✓

SCOPE[120]

2003

    

✓

   

SR[96]

✓

JMIC-B[121]

2004

    

SR[96]

     

VALUE[122-124]

2004

         

✓

  1. a Trials post-dating the guidelines (indicated by the stepped line) were not available to the guideline developers.
  2. b Year of earliest publication.
  3. c Referred only to rationale and design.
  4. ✓ Primary report of trial cited by guideline.
  5. SR Trial included in systematic review cited by guideline; primary report not cited by guideline.