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Table 2 Barriers to prescribing thiazides for the treatment of hypertension, and possible interventions to address these

From: Improving prescribing of antihypertensive and cholesterol-lowering drugs: a method for identifying and addressing barriers to change

Possible barriers

Possible interventions

Physicians are neither familiar with the relevant brand-names nor to the use and follow-up of these drugs

- Pre-printed prescriptions, also in electronic format

- Patient information

- Support for the clinical follow-up

Few other clinicians use these drugs

- Patient information

- Active promotion of thiazides (through educational outreach visits)

- Point out the consensus among guidelines that thiazides are a first-line drug

Specialists may be prescribing other drugs

- Identify opinion leaders that advocate the use of thiazides

- Look into possible conflicts of interest

Advocacy by pharmaceutical companies

- Point attention to the importance of clinically relevant endpoints when studies are quoted (during educational outreach visits)

- Review advertisements to identify the main lines of reasoning that are being used

Physicians are worried about possible side-effects and lack of anti-hypertensive effect.

- Educational outreach visits

Thiazides considered old-fashioned

- Argue that these drugs have been thoroughly tested over many years (during educational outreach visits)