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Table 5 Univariate sensitivity analyses

From: The potential savings of using thiazides as the first choice antihypertensive drug: cost-minimisation analysis

 

Potential savings (per inhabitant)

 

Main scenario

Proportion of the population treated for hypertension increased to 9.4%

Proportion of patients with hypertension and CVD* that can take thiazides increased from 0% to 40%

Proportion of persons treated for hypertension that have CVD* increased from 40% to 50%

Proportion of persons treated for hypertension that have CVD* decreased from 40% to 30%

Proportion of persons with uncomplicated hypertension that can use thiazides decreased from 75% to 65%

Proportion of persons with uncomplicated hypertension that can use thiazides increased from 75% to 85%

Canada

$13.8 million ($0.44)

$94.8 million ($3.03)

$45.6 million ($1.46)

$-7.9 million ($-0.25)

$35.5 million ($1.14)

$-3.6 million ($-0.11)

$31.2 million ($1.00)

France

$37.4 million ($0.63)

$72.8 million ($1.23)

$51.4 million ($0.87)

$28.0 million ($0.47)

$46.9 million ($0.79)

$29.9 million ($0.50)

$45.0 million ($0.76)

Germany

$72.2 million ($0.87)

$158.9 million ($1.92)

$106.3 million ($1.28)

$48.9 million ($0.59)

$95.4 million ($1.15)

$53.6 million ($0.65)

$90.8 million ($1.10)

Norway

$10.7 million ($2.40)

$18.6 million ($4.15)

$14.3 million ($3.19)

$8.3 million ($1.86)

$13.2 million ($2.94)

$8.8 million ($1.96)

$12.7 million ($2.83)

UK

$119.7 million ($2.01)

$119.7 million ($2.01)

$199.8 million ($3.36)

$65.1 million ($1.09)

$174.3 million ($2.93)

$76.0 million ($1.28)

$163.4 million ($2.75)

US

$433.6 million ($1.57)

$808.9 million ($2.94)

$873.5 million ($3.17)

$133.6 million ($0.49)

$733.5 million ($2.66)

$193.6 million ($0.70)

$673.5 million ($2.44)

  1. *cardiovascular disease