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Table 4 Logistic regression of dabigatran use (versus warfarin) among all patients (n = 20,320) and OAC-naïve patients (n = 2,405)

From: Characteristics affecting oral anticoagulant therapy choice among patients with non-valvular atrial fibrillation: a retrospective claims analysis

Independent variables

All-patient cohort†

OAC-naïve cohort#

Odds ratio

95% confidence limits

P-value

Odds ratio

95% confidence limits

P-value

Intercept

-1.34

  

<.0001

-1.26

  

<.0001

Female (reference = male)

0.87

0.79

0.96

0.0035

1.02

0.83

1.26

0.8362

55-64 age group (reference = 18–54)

1.00

0.86

1.16

0.9517

0.90

0.68

1.21

0.4865

65-74 age group

0.64

0.55

0.75

<.0001

0.59

0.43

0.81

0.0010

75-84 age group

0.44

0.37

0.53

<.0001

0.40

0.28

0.58

<.0001

85+ age group

0.39

0.31

0.48

<.0001

0.42

0.26

0.66

0.0002

Midwest region indicator (reference = west)

0.55

0.49

0.62

<.0001

0.43

0.34

0.56

<.0001

Northeast region indicator

0.90

0.80

1.01

0.0816

0.93

0.70

1.23

0.6125

South region indicator

1.05

0.93

1.19

0.4389

1.12

0.85

1.49

0.4282

PPO insurance indicator (reference = HMO)

1.68

1.48

1.92

<.0001

1.47

1.10

1.96

0.0089

Other insurance type indicator

1.31

1.13

1.52

0.0003

1.20

0.87

1.66

0.2770

Total ATRIA score

0.98

0.95

1.00

0.0477

0.91

0.86

0.96

0.0005

Pre-index heart failure

0.78

0.70

0.87

<.0001

0.76

0.59

0.97

0.0253

Pre-index hypertension

1.16

1.04

1.30

0.0083

1.32

1.04

1.69

0.0246

Pre-index warfarin

0.34

0.31

0.38

<.0001

    

Pre-index any anti-platelet/NSAIDS fill

1.15

1.03

1.28

0.0097

    

Prior use of any dyspepsia medication

1.13

1.03

1.25

0.0146

    

Cardiology specialty of index OAC prescriber indicator (reference = PCP/family/internal medicine)

3.12

2.77

3.51

<.0001

3.59

2.68

4.81

<.0001

Other specialty of index OAC prescriber

1.94

1.72

2.20

<.0001

2.22

1.65

2.97

<.0001

Pre-index PT test use

0.70

0.64

0.78

<.0001

    

Pre-index any heart rate/rhythm control medication fill

1.19

1.06

1.34

0.0037

    

Pre-index any Afib related procedure

1.53

1.38

1.71

<.0001

    

Pre-index ischemic stroke

1.34

1.18

1.53

<.0001

1.42

1.06

1.90

0.0183

Pre-index TIA

1.24

1.02

1.51

0.0281

    

Total patient out of pocket pharmacy costs (per $1 K) during the pre-index period

1.04

1.01

1.08

0.0251

1.32

1.17

1.48

<.0001

  1. †C-statistic = 0.7530; Hosmer and Lemeshow Test (p-value = 0.6416).
  2. #C-statistic = 0.7360; Hosmer and Lemeshow Test (p-value = 0.0754).
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