Skip to main content

Table 2 Unit and monthly cost of mCRPC medications

From: Drug costs in the management of metastatic castration-resistant prostate cancer in Canada

Medication Dosage (reference) Unit cost (reference) Cost per month
Primary medication
Bicalutamide (Casodex) 1 × 50 mg daily [17] $1.61 per tablet (50 mg) [42] $58.71
Abiraterone (Zytiga) 4 × 250 mg daily [34] $28.3333 per tablet (250 mg) [42] $3,448
Cabazitaxel (Jevtana) 25 mg/m2 i.v. every 21 days [36] $5,840 per vial (60 mg/1.5 ml) [46] $8,460*
Docetaxel (Taxotere) 75 mg/m2 i.v. every 21 days [26] $599.79 per vial (160 mg/16 ml)** [46] $774*
Prednisone (Deltasone) 2 × 5 mg daily [34] $0.022 per tablet (5 mg)** [42] $1.34
Premedication for chemotherapy-induced side effects
Dexamethasone†‡ 8 mg i.v. every 21 days [26, 36] $3.24 per vial (10 mg/ml, 1 ml)** [46] $4.69
Diphenhydramine 25 mg i.v. every 21 days [36] $2.98 per vial (50 mg/ml, 1 ml)** [46] $4.32
Famotidine 20 mg i.v. every 21 days [36] $2.71 per vial (10 mg/ml, 2 ml)** [46] $3.93
Medication for medical castration
Goserelin (Zoladex) 10.8 mg s.c. every 3 months (13 weeks) [40] $1,113 per 10.8 mg depot 3 months [42] $371
Bone-targeted therapy
Denosumab (XGEVA) 120 mg s.c. every 4 weeks [23] $538.45 per vial (120 mg/1.7 ml) [42] $585
  1. *Based on a body surface area of 1.9 m2. This corresponds to the normal values reported for men in the general population [47]. The chemotherapies’ monthly cost was calculated under the assumption that the patients do not share the vials;
  2. **Cost of generic.
  3. Premedication for cabazitaxel.
  4. Premedication for docetaxel.
\