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Table 6 Monthly regimen costs: Six commonly used regimens

From: Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations

 

Age (years)

RegimenA

0.5

1

2

3

4

5

6

7

8

9

10

11

12

13

LPV/R + ZDV + 3TC

 Scenario 1

$23.22

$26.03

$31.57

$34.08

$23.86

$25.07

$26.05

$27.00

$28.30

$30.07

$32.17

$34.36

$36.42

$38.21

 Scenario 2

$22.38

$24.15

$23.05

$22.96

$23.86

$25.07

$26.05

$27.00

$28.30

$30.07

$32.17

$34.36

$36.42

$38.21

 Scenario 3

$20.10

$21.61

$19.77

$19.64

$21.20

$23.20

$24.59

$25.61

$26.91

$28.76

$31.04

$33.46

$35.69

$37.58

LPV/R + ABC + 3TC

 Scenario 1

$31.89

$35.65

$44.53

$47.46

$29.22

$30.89

$32.25

$33.56

$35.29

$37.52

$40.03

$42.55

$44.81

$46.70

 Scenario 2

$25.73

$27.91

$27.57

$27.91

$29.22

$30.89

$32.25

$33.56

$35.29

$37.52

$40.03

$42.55

$44.81

$46.70

 Scenario 3

$23.45

$25.36

$24.30

$24.59

$26.56

$29.01

$30.79

$32.18

$33.92

$36.23

$38.95

$41.71

$44.16

$46.15

LPV/R + D4T +3TC

 Scenario 1

$23.22

$25.48

$27.22

$28.23

$18.40

$19.03

$19.58

$20.24

$21.40

$23.25

$25.68

$28.31

$30.71

$32.68

 Scenario 2

$23.21

$24.53

$19.81

$18.17

$18.40

$19.03

$19.58

$20.24

$21.40

$23.25

$25.68

$28.31

$30.71

$32.68

 Scenario 3

$18.42

$19.73

$17.50

$17.16

$18.52

$20.29

$21.47

$22.26

$23.22

$24.64

$26.46

$28.46

$30.40

$32.15

NVP OR EFV + ZDV + 3TC B

 Scenario 1

$11.72

$13.15

$15.80

$13.96

$13.37

$13.72

$14.11

$14.59

$15.15

$15.63

$15.89

$15.92

$15.71

$15.32

 Scenario 2

$10.24

$11.47

$14.04

$12.89

$13.37

$13.72

$14.11

$14.59

$15.15

$15.63

$15.89

$15.92

$15.71

$15.32

 Scenario 3

$5.86

$6.58

$7.93

$9.57

$10.71

$11.85

$12.65

$13.21

$13.76

$14.31

$14.77

$15.01

$14.98

$14.68

NVP OR EFV + ABC + 3TC B

 Scenario 1

$20.40

$22.77

$28.76

$27.34

$18.73

$19.54

$20.31

$21.16

$22.14

$23.07

$23.75

$24.10

$24.09

$23.80

 Scenario 2

$13.59

$15.23

$18.56

$17.84

$18.73

$19.54

$20.31

$21.16

$22.14

$23.07

$23.75

$24.10

$24.09

$23.80

 Scenario 3

$11.31

$12.68

$15.28

$14.52

$16.06

$17.66

$18.85

$19.78

$20.76

$21.79

$22.68

$23.26

$23.45

$23.25

NVP OR EFV + D4T +3TC B

 Scenario 1

$11.72

$12.60

$11.45

$8.11

$7.90

$7.68

$7.64

$7.84

$8.24

$8.81

$9.41

$9.86

$10.00

$9.79

 Scenario 2

$11.07

$11.85

$10.80

$8.11

$7.90

$7.68

$7.64

$7.84

$8.24

$8.81

$9.41

$9.86

$10.00

$9.79

 Scenario 3

$3.35

$3.76

$4.53

$7.10

$8.03

$8.94

$9.53

$9.85

$10.07

$10.20

$10.18

$10.01

$9.69

$9.25

  1. Abbreviations: ABC abacavir, d4T stavudine, 3TC lamivudine, EFV efavirenz, LPV/r lopinavir/ritonavir, NVP nevirapine, ZDV zidovudine,
  2. A. ARV availability scenarios (see also Methods):
  3. Scenario 1 (No FDCs, Late Switch): Coformulations are not available. Liquid formulations of all drug components are used until 4 years of age, and then children switch to pediatric/adult tablets as recommended by weight-based dosing.
  4. Scenario 2 (No FDCs, Early Switch): Coformulations are not available. Liquid formulations of all drug components are used until 6 months of age, and then children switch to pediatric/adult tablets as recommended by weight-based dosing.
  5. Scenario 3 (Available FDCs, Early Switch): Coformulations are available. Coformulated pediatric tablets, if they exist, are used from birth. If all drug components are not included in the coformulation, liquid formulations of the remaining drugs are used until 6 months of age, and then children switch to pediatric/adult tablets as recommended by weight-based dosing.
  6. B. Patients on the non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are assumed to receive NVP until age 3, then EFV at age 3 and after because EFV is not yet approved for children less than 3 years of age or 10kg of weight.
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BMC Health Services Research

ISSN: 1472-6963

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