a: Extreme scenarios and variations in the duration of stable VE | |||||
---|---|---|---|---|---|
 | Base-case | Extreme scenario |  | ||
 |  | Best case | Worst case | ||
ICER by outcome | Â | Â | Â | ||
€/HZ-case avoided | 1,419 | 17 | 4,595 | ||
€/PHN-case avoided | 20,809 | 163 | 327,691 | ||
€/QALY gained | 28,146 | 235 | 157,845 | ||
b: Duration of stable VE [years] | |||||
 | 0 | 5 | 10 (base-case) | 15 | 20 |
ICER by outcome | Â | Â | Â | Â | Â |
€/HZ-case avoided | 2,633 | 1,800 | 1,419 | 1,225 | 1,123 |
€/PHN-case avoided | 40,300 | 27,057 | 20,809 | 17,708 | 16,128 |
€/QALY gained | 53,702 | 36,211 | 28,146 | 24,060 | 21,931 |
c: Booster scenarios [by age at vaccination in years] | |||||
 | Base-case | Best case | |||
 |  | 50 | 60 | 70 | 80 |
ICER by outcome | Â | Â | Â | Â | Â |
€/HZ-case avoided | 1,419 | 1,080 | 1,361 | 2,701 | 9,372 |
€/PHN-case avoided | 20,809 | 19,001 | 19,632 | 22,931 | 35,604 |
€/QALY gained | 28,146 | 30,241 | 32,173 | 46,126 | 93,497 |
 | Base-case | Worst case | |||
 |  | 50 | 60 | 70 | 80 |
ICER by outcome | Â | Â | Â | Â | Â |
€/HZ-case avoided | 1,419 | 1,580 | 1,621 | 2,792 | 9,384 |
€/PHN-case avoided | 20,809 | 29,095 | 22,643 | 23,345 | 35,619 |
€/QALY gained | 28,146 | 52,628 | 39,604 | 47,559 | 93,565 |
d: Variations in the length of PHN [month] | |||||
 | 6 | 9 (base-case) | 15 | 36 |  |
ICER by outcome | Â | Â | Â | Â | Â |
€/QALY gained | 31,741 | 28,146 | 23,048 | 4,149 |  |