Table 1 RCT Sub-studies and Process and Outcome Measures

Sub-study 1: patients with clinically significant depressive symptoms (baseline PHQ-9 ≥ 5)

   Process of care

     Key outcome - components of initial depression care (CIDC): antidepressant prescription and/or mental health referral among participants with baseline PHQ-9 ≥ 10*

     Others

       Antidepressant prescription and/or mental health referral among all sub-study participants*

       Follow-up with PCP at an appropriate interval†

       Inquiry regarding self-harm/suicidal thoughts

   Patient function

     PHQ-8^‡ score

     SF-12 Mental Component Summary score

     SF-12 Physical Component Summary score

   Patient engagement in depression care

     Readiness

       To discuss depression (in general) with PCP

       To discuss depression treatment with PCP

     Self-efficacy

       For recognizing depression

       For discussing depression with PCP

     Provider-patient interaction

       Discussion of depression

       Patient request for depression treatment

   Patient perceived depression stigma

Sub-study 2: patients without clinically significant depressive symptoms (baseline PHQ-9 < 5)

   Process of care

     Antidepressant prescription (over-treatment)

     Distraction effects

       Index office visit length

       Patient request for depression treatment

       Physician visit effort

   Patient function

     SF-12 Physical Component Summary score (potential toxicity, i.e. reduced function)

     Patient perceived depression stigma (potential reduction)