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Table 5 Unintentional Non-Adherence as a Mediator on the Direct Effect of Patient Beliefs on Intentional Non-Adherence (N = 24,017)

From: Unintentional non-adherence to chronic prescription medications: How unintentional is it really?

  Model 1 Direct effect of patient beliefs on unintentional non-adherence Model 2 Direct effect of unintentional non-adherence on intentional non-adherence Model 3 Total effect of patient beliefs on intentional non-adherence Model 4 Direct effect of patient beliefs on intentional non-adherence controlling for unintentional non-adherence
  Pathway a in Figure 1 Pathway b in Figure 1 Pathway c in Figure 1 Pathway c’ in Figure 1
  DV = unintentional non-adherence DV = intentional non-adherence DV = intentional non-adherence DV = intentional non-adherence
  B (95% CI)
Predictor Variables  
Perceived Need for Prescription     
Quartile 1 9.2* (7.8–10.7)   4.1* (3.4–4.9) 2.7* (1.9–3.4)
Quartile 2 7.5* (6.3–8.2)   1.9* (1.3–2.6) 0.8* (0.2–1.4)
Quartile 3 5.1* (3.9–6.2)   0.6 (−0.1–1.2) −0.2 (−0.8–0.4)
Prescription Affordability     
Quartile 1 18.5* (17.2–19.8)   11.9* (11.2–12.6) 9.0* (8.4–9.7)
Quartile 2 10.0* (8.7–11.3)   5.3* (4.6–5.9) 3.7* (3.1–4.4)
Quartile 3 5.1* (3.9–6.2)   1.5* (0.9–2.1) 0.7* (0.1–1.3)
Prescription Concerns     
Quartile 1 4.5* (3.0–6.0)   7.7* (6.9–8.5) 7.0* (6.3–7.8)
Quartile 2 3.3* (2.1–4.6)   2.5* (1.8–3.1) 2.0* (1.3–2.6)
Quartile 3 2.8* (1.6–4.0)   1.1* (0.4–1.7) 0.6* (0.1–1.2)
Unintentional Non-Adherence   0.2* (0.2–0.2)   0.2* (0.1–0.2)
  1. * p < 0.05; DV = Dependent variable for the specific model being tested.