Table 1 Associations between receiving Chronic Myeloid Leukemia (CML) treatment initiation and patient characteristics
Characteristics | 1998a | 2004 | 2007 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n (%) | χ2 | OR | p | n (%) | χ2 | OR | p | n (%) | χ2 | OR | p | |
(p-value) | (95%CI)b | (p-value) | (95%CI) | (p-value) | (95%CI) | |||||||
Age at diagnosis, years | ||||||||||||
≥40 | 228 (81.1) | 9.16 (<0.01) | 0.4 (0.2-0.8) | <0.01 | 160 (74.4) | 6.30 (0.01) | 0.5 (0.2-0.9) | 0.03 | 186 (72.1) | 16.86 (<.0001) | 0.4 (0.2-0.7) | <0.01 |
<40 | 53 (18.9) | 1 (referent) | 55 (25.6) | 1 (referent) | 72 (27.9) | 1 (referent) | ||||||
Gender | ||||||||||||
Male | 166 (59.1) | 0.00 (0.95) | 0.8 (0.4-1.7) | 0.60 | 126 (58.6) | 1.25 (0.26) | 0.7 (0.4-1.3) | 0.26 | 151 (58.5) | 0.49 (0.49) | 1.4 (0.8-2.3) | 0.29 |
Female | 115 (40.9) | 1 (referent) | 89 (41.4) | 1 (referent) | 107 (41.5) | 1 (referent) | ||||||
Charlson comorbidity score | ||||||||||||
≥1 | 101 (35.9) | 0.00 (0.97) | 1.2 (0.6-2.4) | 0.71 | 118 (54.9) | 3.71 (0.05) | 0.6 (0.4-1.2) | 0.13 | 140 (54.3) | 20.36 (<.0001) | 0.4 (0.2-0.6) | <0.001 |
=0 | 180 (64.1) | 1 (referent) | 97 (45.1) | 1 (referent) | 118 (45.7) | 1 (referent) | ||||||
CML severity | ||||||||||||
high severity | 45 (16.0) | 17.90 (<.0001) | 4.3 (2.0-9.3) | <0.001 | 28 (13.0) | 1.64 (0.20) | 2.1 (0.8-5.4) | 0.12 | 40 (15.5) | 2.87 (0.09) | 2.3 (1.1-5.1) | 0.04 |
less severity c | 236 (84.0) | 1 (referent) | 187 (87.0) | 1 (referent) | 218 (84.5) | 1 (referent) | ||||||