Cost-effectiveness of counselling, graded-exercise and usual care for chronic fatigue: evidence from a randomised trial in primary care

Table 2 Adjusted ¹ differences in costs and outcomes and incremental cost-effectiveness ratios

	GET vs BUC		COUN vs BUC		GET vs COUN
	Difference (95%CI)	p	Difference (95%CI)	p	Difference (95%CI)	p
Costs differences	261(141 to 382)	<0.001	423 (288 to 559)	<0.001	−202 (−362 to −43)	0.013
Chalder improvements differences	1.1 (−2.3 to 4.4)	0.530	−0.1 (−3.1 to 2.9)	0.969	0.7 (2.6 to −4.0)	0.663
ICER per CSI	987		COUN dominated strategy		COUN dominated strategy

GET = graded exercise therapy, BUC = booklet plus usual care, COUN = counselling, ICER = incremental cost-effectiveness ratio, CSI = clinically significant improvement.
1. adjusted by the following baseline characteristics: gender, age, whether the patient lived alone, whether the patient had dependants, symptom level, level of depression, level of anxiety, level of social functioning, baseline fatigue score, number of months since chronic fatigue began, and baseline health care cost.

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