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Table 1 Adoption times for medicines adopted in Australia, by drug class

From: Nation-scale adoption of new medicines by doctors: an application of the Bass diffusion model

Medicine (INN), by Anatomical main group (ATC) Month of the first subsidised prescription Maximum monthly prescriptions (per 100,000 Australians) p/q ratio from Bass diffusion model Model fit for Bass diffusion model (R2) Modelled Adoption time (years)
Alimentary tract and metabolism
Esomeprazole Mar 2002 2755 5.87×10-1 0.990 8.67
Clarithromycin* Dec 1998 384 1.50×109 0.865 14.08
Granisetron Dec 2003 45 3.30×10-2 0.986 5.58
Ursodeoxycholic acid* Jun 2000 13 8.50×109 0.948 9.75
Balsalazide Mar 2005 9 1.08×10-1 0.995 4.58
Insulin lispro Jun 1996 30 4.52×10-1 0.973 6.75
Insulin glargine May 2006 113 5.57×10-1 0.961 5.50
Glimepiride Jun 2000 263 3.40×10-2 0.981 2.42
Rosiglitazone Jun 2003 228 3.40×10-2 0.969 4.17
Pioglitazone Jun 2003 226 1.21×10-1 0.912 8.83
Acarbose Jun 1997 38 6.20×10-2 0.991 2.25
Blood and blood forming organs
Enoxaparin Nov 1993 123 4.00×10-3 0.990 14.42
Clopidogrel Apr 1999 1327 2.69×10-1 0.994 11.33
Ticlopidine Nov 1992 15 1.90×10-2 0.976 6.08
Dipyridamole Mar 1999 74 1.10×10-2 0.962 1.17
Abciximab Dec 1995 2 5.00×10-2 0.965 5.83
Tirofiban Jun 1999 1 3.37×10-1 0.979 4.92
Cardiovascular system
Nicorandil Sep 1997 110 6.97×10-1 0.979 13.58
Eplerenone Sep 2005 5 1.19×10-1 0.986 5.00
Bisoprolol Mar 2002 211 2.80×10-2 0.983 9.08
Carvedilol Dec 1997 256 1.39×10-1 0.991 9.50
Amlodipine* Mar 1993 1378 1.86×109 0.863 12.92
Lisinopril Apr 1992 744 1.79×10-1 0.992 4.92
Perindopril Mar 1992 3174 4.60×10-2 0.991 18.08
Ramipril Apr 1992 1550 5.60×10-2 0.976 14.83
Quinapril Sep 1992 453 8.00×10-3 0.953 7.25
Fosinopril* Apr 1992 491 2.45 0.933 8.75
Trandolapril Nov 1994 424 6.90×10-2 0.980 4.58
Eprosartan Apr 1999 98 3.50×10-2 0.983 6.25
Irbesartan Dec 1997 3333 6.51×10-1 0.992 9.33
Candesartan Sep 1998 1640 1.02×10-1 0.995 11.83
Telmisartan Jun 1999 1535 1.07×10-1 0.969 12.25
Pravastatin Jan 1993 895 9.20×10-2 0.991 10.58
Fluvastatin Sep 1995 223 2.80×10-2 0.952 1.83
Atorvastatin Sep 1997 5096 8.67×10-1 0.987 13.42
Rosuvastatin Jun 2006 1967 3.60×10-2 0.990 3.83
Fenofibrate Mar 2004 250 3.00×10-2 0.991 6.00
Ezetimibe* Mar 2004 419 1.30 0.974 6.17
Dermatologicals
Fluconazole* May 1992 11 2.83×108 0.909 23.33
Imiquimod Nov 2005 14 1.33×10-1 0.952 1.42
Fluticasone Mar 1995 552 1.20×10-2 0.979 5.17
Tacrolimus Mar 2003 6 2.46×10-1 0.967 9.92
Finasteride* Jun 1995 25 1.71 0.838 18.50
Genito urinary system and sex hormones
Raloxifene May 1999 153 4.80×10-2 0.994 2.75
Alprostadil Jun 1995 64 2.00×10-3 0.989 2.42
Antiinfectives for systemic use
Roxithromycin Jun 1992 1244 7.50×10-1 0.972 5.33
Azithromycin Jan 1995 47 1.26×10-1 0.916 17.17
Itraconazole* Jun 1997 3 1.94×108 0.955 8.75
Famciclovir* Jun 1995 64 4.79×1011 0.902 17.08
Valaciclovir Mar 1996 160 1.54×10-1 0.997 13.50
Antineoplastic and immunomodulating agents
Temozolomide Sep 1999 5 5.98×10-1 0.910 12.33
Gemcitabine Dec 1995 9 2.08×10-1 0.974 8.50
Capecitabine* Jun 1999 9 2.22 0.928 8.58
Vinorelbine Jun 1998 1 4.10×10-2 0.980 2.00
Paclitaxel May 1994 9 2.96×10-1 0.942 17.92
Docetaxel Mar 1996 9 5.39×10-1 0.850 19.25
Oxaliplatin Jun 2001 8 4.46×10-1 0.971 5.00
Rituximab Sep 1998 18 1.85×10-1 0.983 10.50
Imatinib Jul 2001 9 1.70×10-2 0.976 1.92
Irinotecan Dec 1999 5 8.00×10-3 0.865 1.08
Nilutamide Dec 1996 2 3.10×10-2 0.977 1.92
Anastrozole Mar 1997 89 2.00×10-3 0.982 12.42
Letrozole Dec 1997 51 6.00×10-2 0.928 15.42
Exemestane Aug 2000 9 2.03×10-1 0.921 11.67
Interferon beta1a* Sep 1998 16 2.87×107 0.977 9.75
Interferon alfa2a Jul 1992 1 1.20×10-2 0.900 8.33
Leflunomide* Sep 1999 78 2.87×109 0.948 12.58
Etanercept Mar 2003 27 8.60×10-2 0.989 7.58
Adalimumab Dec 2003 36 1.90×10-2 0.980 6.92
Musculo-skeletal system
Rofecoxib Jun 2000 1281 1.40×10-2 0.963 1.75
Celecoxib Jun 1999 1806 2.00×10-3 0.981 1.58
Alendronic acid Jun 1996 955 9.00×10-3 0.991 8.25
Risedronic acid Sep 2000 583 6.20×10-2 0.993 8.42
Nervous system
Fentanyl Mar 1999 203 6.00×10-3 0.910 12.25
Tramadol Apr 1999 954 1.10×10-2 0.962 4.33
Oxcarbazepine* May 1999 6 3.84 0.955 8.42
Lamotrigine Jul 1994 146 7.11×10-1 0.984 17.17
Topiramate Mar 1997 87 1.80×10-1 0.921 18.25
Gabapentin Jul 1994 75 8.10×10-2 0.974 14.67
Flupentixol Mar 1994 8 4.99×10-1 0.988 5.08
Zuclopenthixol Jun 1996 10 1.21×10-1 0.956 6.83
Olanzapine* Mar 1997 391 1.87 0.961 11.08
Quetiapine Jun 2000 262 5.90×10-2 0.950 11.75
Amisulpride Mar 2002 36 8.60×10-2 0.952 2.42
Risperidone Sep 1994 268 9.10×10-2 0.927 17.67
Aripiprazole* Dec 2003 47 5.50 0.975 5.50
Citalopram Sep 1997 757 6.30×10-2 0.994 5.50
Paroxetine Mar 1994 581 1.33×10-1 0.996 5.92
Sertraline Mar 1994 1181 3.55×10-1 0.985 9.67
Fluvoxamine Mar 1997 183 2.21×10-1 0.997 8.00
Venlafaxine Mar 1996 1167 1.15×10-1 0.990 12.83
Methylphenidate Feb 2005 156 6.50×10-2 0.992 3.92
Donepezil Apr 1999 102 3.83×10-1 0.955 6.75
Rivastigmine Mar 2000 13 1.00×10-3 0.946 1.42
Galantamine Jun 2001 47 1.10×10-1 0.996 4.92
Acamprosate Jun 1999 12 2.40×10-2 0.944 0.92
Riluzole* Feb 2003 3 3.49×105 0.975 6.08
Respiratory system
Nedocromil Nov 1994 115 5.00×10-2 0.986 2.08
Salmeterol Sep 1994 1362 1.10×10-2 0.944 10.00
Formoterol Dec 1996 644 8.90×10-2 0.948 16.75
Tiotropium* Sep 2002 748 3.537 0.969 8.50
Montelukast* Sep 2002 78 4.82 0.969 7.08
Sensory organs
Latanoprost* Dec 1997 689 2.99×109 0.923 7.92