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Table 2 Adherence and clinical outcome measures at visit nearest to 180 days after initiation or at second CD4 test in subgroup with test in months 4 to 9.

From: Measuring adherence to antiretroviral treatment in resource-poor settings: The clinical validity of key indicators

 

Total

(n = 488)

With CD4 test

(n = 409)

Average number of days since treatment initiation (min, max)

178

(124,337)

188

(98,270)

Dispensing-based adherence

  

% of days covered since ART start

  

   < 80%

2.9%

2.4%

   80% to <85%

2.7

2.0

   85% to <90%

2.9

3.9

   90% to <95%

8.0

8.1

   95% to <100%

20.1

19.6

   100%

63.5

64.1

% with gap in treatment >30 days

2.7%

3.4%

Self-report adherence

  

Average (s.d.) number of self-reports recorded in medical record during follow-up

5.7 (1.8)

5.4 (2.0)

Average (s.d.) of all self-reports *

1.17 (0.39)

1.16 (0.33)

% all self-reports perfect *

72.6%

74.4%

% any self-report poor *

3.0%

2.9%

Appointment keeping

  

Average number (s.d.) of visits

6.4 (1.1)

6.0 (1.6)

% visits on/before scheduled day

  

   < 80%

19.9%

18.1%

   80% to <90%

22.1

20.5

   90% to 100%

58.1

61.4

% visits ≤ 3 days after scheduled

  

   < 80%

5.9%

5.7%

   80% to <90%

13.1

11.1

   90% to 100%

81.0

83.2

Dispensing-based appointment keeping

  

% of visits before finishing ARVs dispensed during previous visit

  

   < 80%

44.9%

44.0%

   80% to <90%

27.5%

27.1

   90% to 100%

27.7%

28.9

Change in clinical outcome measures

  

Average (s.d.) increase in CD4 count

NA

138.1 (125.5)

Average (s.d.) weight gain (kg)

3.9 (5.1)

3.8 (4.8)

  1. * Self-reports were recorded in medical records as perfect (coded as 1), good (2), or poor (3); cases from Ethiopia (n = 120 total, n = 96 with CD4 test) were excluded from analysis because self-reports there were recorded as good/fair vs. poor.