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Table 4 Drug group and diagnoses most frequently associated with ADR.

From: Trends of adverse drug reactions related-hospitalizations in Spain (2001-2006)

  ICD-9-CM code Frequency Percentage CI 95%
Drug group    
Antineoplastic and immunosuppressive drugs E933.1 75,760 21.5 (21.2-21.7)
Adrenal cortical steroids E932.0 47,539 13.5 (13.1-13.8)
Anticoagulants E934.2 26,546 7.5 (7.1-7.8)
Cardiotonic glycosides E942.1 24,662 7.0 (6.6-7.3)
Antibiotics E930.8-E930.9 22,144 6.3 (5.9-6.6)
Diuretics E944.4 21,818 6.2 (5.8-6.5)
Antirheumatics E935.6 12,859 3.6 (3.2-.39)
Cardiac rhythm regulators E942.0 11,943 3.4 (3.0-3.7)
Unspecified drug or medicinal substance E947.9 11,134 3.2 (2.8-3.5)
Diagnoses    
Neutropenia, unspecified 288.0 17,803 5.0 (4.6-5.3)
Obstructive chronic bronchitis 491.21 17,239 4.9 (4.5-5.2)
Congestive heart failure 428.0 11,135 3.1 (2.7-3.4)
Encounter for chemotherapy and immunotherapy for neoplastic conditions V58.1 10,840 3.0 (2.6-3.3)
Pneumonia 486 10,244 2.9 (2.5-3.2)
Diseases of respiratory system 519.8 6,951 1.9 (1.5-2.2)
Aplastic anemias 284.8 5,985 1.7 (1.3-2.0)
Other and unspecified adverse effect of drug 995.2 4,968 1.4 (1.0-1.7)
Acute renal failure 584.9 4,787 1.3 (0.9-1.6)
Toxic gastroenteritis and colitis 558.2 4,444 1.2 (0.8-1.5)
  1. Minimum Basic Data Set, 2001-2006. International Classification of diseases (9th Edition) - clinical Modification