Table 1 Model parameters point estimate values and ranges
Parameter | Point estimate | Plausible Range | Distribution | Reference | ||
|---|---|---|---|---|---|---|
Treatment efficacy (success rate, %) | ||||||
Fluconazole | 63.0 | 57.0–74.0 | Beta | Mills et al., 2009 [21] | ||
Caspofungin | 76.1 | 63.6–78.0 | Beta | Mills et al., 2009 [21] | ||
L-AmB | 72.9 | 66.4–76.0 | Beta | Mills et al., 2009 [21] | ||
Mortality rate (%) | ||||||
Fluconazole | 28.4 | 16.6–31.4 | Beta | Mills et al., 2009 [21] | ||
Caspofungin | 33.8 | 26.4–34.2 | Beta | Mills et al., 2009 [21] | ||
IC/C recurrence rate (%) | 4.4 | 1.4–13.0 | Beta | Ásmundsdóttir et al., 2012; Muñoz et al., 2016; Reboli et al.,2007; Pappas et al., 2007 | ||
Utilities | ||||||
Patient with IC/C | 0.72 | 0.50–0.94 | Beta | CEA Registry, Tufts Medical Center [25] | ||
Healthy or survivors | 0.94 | 0.84–0.94 | Beta | |||
Costs (US$) | ||||||
Loading dose cost | ||||||
Fluconazole 800 mg per day | $3 | $2–5 | Gamma | TASH and MCM | ||
Caspofungin 70 mg per day | $179 | $150–200 | Gamma | MCM | ||
L-AmB (3 mg/kg per day for an average weight of 70 kg) | $198 | $190–215 | Gamma | TASH and MCM | ||
Maintenance dose | ||||||
Fluconazole 400 mg per day | $17 | $15–30 | Gamma | TASH and MCM | ||
Caspofungin 50 mg per day | $2322 | $2000–2500 | Gamma | MCM | ||
L-AmB (3 mg/kg per day for an average weight of 70 kg) | $2574 | $500–2,700 | Gamma | TASH and MCM | ||
Hospitalization cost per day | $5 | $1–35 | Gamma | TASH and MCM | ||
Diagnostic and monitoring costs | $76 | $50–100 | Gamma | TASH and MCM | ||