Fig. 1

Identification of the “switch population”. Abbreviations: COPD: chronic obstructive pulmonary disease; MITT: multiple inhaler triple therapy; SITT: single inhaler triple therapy; ICS: inhaled corticosteroids; LABA: long-acting beta2-agonists; LAMA: long-acting antimuscarinic agents. *Data extraction from the National Statistical Institute (ISTAT) referring to the general and resident population in the Apulia Region surveyed on January 1, 2017; **Internal processing based on the prescriptive data offered by the Longitudinal Prescription Database (LRx) of IQVIA™ and combined with the medical audit diagnosis service (reference period: 2017); ***Costs were calculated assuming incremental market penetration shares (Market Share) of ICS/LAMA/LABA equal to 30%, 50% and 100%