Table 2 Cost inputs used in model

Drug

Price per pack

Packaging

Daily cost

Lurasidone (adolescents) (80 mg)

£90.72 [26]

28 × 74 mg tablets

£3.50

Lurasidone (adults) (148 mg)

£90.72 [26]

28 × 74 mg tablets

£6.48

Haloperidol (3 mg)

£4.48 [27]

5 mg/5 ml 100 ml solution

£0.13

Paliperidone (6 mg)

£97.28 [28]

28 × 6 mg tablets

£3.47

Aripiprazole (10 mg)

£0.59 [27]

28 × 5 mg tablets

£0.04

Brexpiprazole (4 mg)^a

£104.47

28 × 6 mg tablets

£2.49

Cariprazine (6 mg)

£80.36 [29]

28 × 6 mg tablets

£2.87

Clozapine (325 mg)

£6.32 [27]

84 × 25 mg tablets

£0.98

Item

Total six-weekly costs (per patient)

Stable

Relapse

Outpatient, primary, community care and residential care (adults)

£2,000 [3, 13, 27, 30,31,32,33]

£27,906 [3, 13, 27, 30,31,32,33]

Outpatient, primary, community care and residential care (adolescents)

£701 [3, 13, 27, 30,31,32,33]

£28,692 [3, 13, 27, 30,31,32,33]

Item

Weight Gain

Acute EPS

Total cost per adverse event

£92 [3, 14, 27, 30,31,32,33]

£220 [13, 27, 30,31,32,33]