Cycle | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
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HR | 8.5 | 4.72 | 3.58 | 2.97 | 2.63 | 2.21 | 2.15 | 1.83 | 1.86 | 1.5 | 1.51 | 1.42 | 1.22 | 1.19 | 1.16 |
- Abbreviation: HR hazard ratio
- Notes: 1. The incidence, timing, risk factors and outcomes of neurological events (stroke and TIA) after TAVI were analysed in the high-risk and inoperable cohorts of the PARTNER trial. Time-related events, including mortality following a neurological event, were then estimated by the Kaplan–Meier method (from Kapadia et al., 2016) [32]. HRs of mortality in patients with and without stroke were then derived using data on survival after stroke and expected survival had a stroke not occurred