Table 4 Unit costs and resource use values

VN treatment

Acquisition cost (public price) of VN

1

759'968

Novartis

Cost of retinal surgery

2 administrations (1 per eye)

3474

[25]; unit cost Swiss-specific: [38]

Cost of prednisone

Regimen cost for both eyes

86

[25]; unit cost Swiss-specific: [32]

Cost of control visits with optical coherence tomography

4

271

[25]; unit cost Swiss-specific: [38]

Adverse events

Cataract

Once in 15% of VN patients

4’869

[7, 8, 10, 25]; unit costs Swiss-specific: [37, 38]

Eye inflammation

Once in 10% of VN patients

52

[7, 8, 10, 25]; unit costs Swiss-specific: [38]

Elevated intraocular pressure

Once in 20% of VN patients

220

[7, 8, 10, 25]; unit costs Swiss-specific: [38]

Testing prior to VN treatment

Testing for viable retinal cells

All IRD patients with RPE65 mutation are tested. It is estimated by medical examiners in Study 301/302, that 55% have sufficient viable cells and 45% do not

271 / 0.55 = 493

[25]; unit costs Swiss-specific: [38]

Costs of visual impairment

Excess hospitalisations in HS2-5 patients aged 65+ years

Compared to HS1 patients aged 65+ years, 0.2 additional hospitalisations per year

12’543 per hospitalisation

[39] Unit costs Swiss-specific: [34, 35]

Technical assistance (including vision aids)

Relative levels of resource use estimated at 1.00 for all HS1 patients, 0.96 for HS2-5 patients aged 18-64 years, and 1.34 for HS2-5 patients aged 65+ years

2’133 per year

[40] Unit costs Swiss-specific: [33]

Community care (Spitex)

6% of HS2-5 patients aged 65+ years

7’063 per year

[41] Unit costs Swiss-specific: [36, 42, 43]

Residential care

30% of HS2-5 patients aged 65+ years

64’537 per year

[41] Unit costs Swiss-specific: [36, 42, 43]

Societal costs (scenario analysis)

Excess education costs of HS2-5 patients aged below 18 years

All relevant patients

21’094 per year

[44] Unit costs Swiss-specific: [31, 35]

Productivity loss of HS2-5 patients aged 18-64 years

80% reduction to average worker’s annual salary of CHF 42,843

42’843 per year

[45] Unit cost Swiss-specific: [35, 36]

Productivity loss of family caregivers of patients aged 65+ years

Annually, 144 hours for HS1 patients, 676 hours for HS2 patients, 1608 hours for HS3-5 patients; conservatively accounted for only 25% of caregiving hours for all patients.

43 per hour

[46] Unit cost Swiss-specific: [35]