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Table 4 Unit costs and resource use values

From: Cost-effectiveness of voretigene neparvovec in the treatment of patients with inherited retinal disease with RPE65 mutation in Switzerland

Cost element Resource use: number and unit description (where relevant) Unit cost (CHF) Sources
VN treatment
Acquisition cost (public price) of VN 1 759'968 Novartis
Cost of retinal surgery 2 administrations (1 per eye) 3474 [25]; unit cost Swiss-specific: [38]
Cost of prednisone Regimen cost for both eyes 86 [25]; unit cost Swiss-specific: [32]
Cost of control visits with optical coherence tomography 4 271 [25]; unit cost Swiss-specific: [38]
Adverse events
Cataract Once in 15% of VN patients 4’869 [7, 8, 10, 25]; unit costs Swiss-specific: [37, 38]
Eye inflammation Once in 10% of VN patients 52 [7, 8, 10, 25]; unit costs Swiss-specific: [38]
Elevated intraocular pressure Once in 20% of VN patients 220 [7, 8, 10, 25]; unit costs Swiss-specific: [38]
Testing prior to VN treatment
Testing for viable retinal cells All IRD patients with RPE65 mutation are tested. It is estimated by medical examiners in Study 301/302, that 55% have sufficient viable cells and 45% do not 271 / 0.55 = 493 [25]; unit costs Swiss-specific: [38]
Costs of visual impairment
Excess hospitalisations in HS2-5 patients aged 65+ years Compared to HS1 patients aged 65+ years, 0.2 additional hospitalisations per year 12’543 per hospitalisation [39] Unit costs Swiss-specific: [34, 35]
Technical assistance (including vision aids) Relative levels of resource use estimated at 1.00 for all HS1 patients, 0.96 for HS2-5 patients aged 18-64 years, and 1.34 for HS2-5 patients aged 65+ years 2’133 per year [40] Unit costs Swiss-specific: [33]
Community care (Spitex) 6% of HS2-5 patients aged 65+ years 7’063 per year [41] Unit costs Swiss-specific: [36, 42, 43]
Residential care 30% of HS2-5 patients aged 65+ years 64’537 per year [41] Unit costs Swiss-specific: [36, 42, 43]
Societal costs (scenario analysis)
Excess education costs of HS2-5 patients aged below 18 years All relevant patients 21’094 per year [44] Unit costs Swiss-specific: [31, 35]
Productivity loss of HS2-5 patients aged 18-64 years 80% reduction to average worker’s annual salary of CHF 42,843 42’843 per year [45] Unit cost Swiss-specific: [35, 36]
Productivity loss of family caregivers of patients aged 65+ years Annually, 144 hours for HS1 patients, 676 hours for HS2 patients, 1608 hours for HS3-5 patients; conservatively accounted for only 25% of caregiving hours for all patients. 43 per hour [46] Unit cost Swiss-specific: [35]
  1. KEY: AE adverse event, CHF Swiss francs, HS health state, N/A not applicable, PSA probabilistic sensitivity analysis, RU resource use, VN voretigene neparvovec