Table 9 Description of Studies: Multiple Sclerosis
Authors, Year | Condition | CEA | CUA | Setting | N (participants) | Baseline Characteristics | Intervention/ comparator(s) | Effectiveness measure(s); cost measures (price year) | Perspective | Time horizon |
|---|---|---|---|---|---|---|---|---|---|---|
Bogosian et al. 2015 [36*] | MS | ✓ | ✓ | UK; | N Participants: | 40 | Manualised mindfulness groups based on MBCT 8x1hr sessions delivered via Skype, run by health psychologist who had completed mindfulness teacher training vs waiting list control. Mindfulness: 19 WL: 21 | QALYs (EQ-5D); | Health and social care, patient (informal care) | 3mths |
Primary and hospital care patients recruited via NHS and MS charity | Age in years (mean, SD): | Mindfulness: 53.4 (8.3) WL: 50.9 (9.9) | GBP (2012-13) | |||||||
Sex (% female): | Mindfulness: 47.4 WL: 61.9 | |||||||||
Ethnicity (% white): | Mindfulness: 89.5 WL: 90.5 | |||||||||
Humphreys et al. 2013 [52*] | MS | ✓ | ✓ | UK; | N Participants: | 151 | Adjustment group (6wk x3hrs) run by assistant and clinical psychologist vs standard care (no psychological interventions). Group: 72 SC: 79 | HADS, QALYs (EQ-5D); | Healthcare | 8mths |
Hospital based | Age in years (mean, SD): | Intervention 44.5 (11.1); Control: 47.5 (10.5) | GBP 2009 | |||||||
Sex (% female): | Intervention: 75; Control: 70 | |||||||||
Ethnicity (% white): | Not given | |||||||||
Mosweu et al. 2017 [79*] | MS | ✓ | ✓ | UK; | N Participants: | 94 | 8 sessions nurse delivered CBT (2 F2F and 6 telephone) versus supportive listening (SL) CBT: 48 SL: 46 | QALYs (EQ-5D-3L); GHQ-12 score; | Health social and indirect care perspectives | 12mths |
Hospital based (multi-centre) | Age in years (mean): | CBT: 40; SL: 43 | GBP (2008/09) | |||||||
Sex (% female): | CBT: 73 SL: 65 | |||||||||
Ethnicity (% white): | CBT: 79; SL: 72 | |||||||||
MS | ✓ | ✓ | UK: 3 sites in southwest England, recruitment via primary, secondary care and MS Society | N Participants: | 164 | Manualised group programme (FACETS) based on cognitive behavioural, energy management and self efficacy theories. 6x90min sessions delivered by MDT staff vs current local practice alone (CLP) e.g. general fatigue and MS management advice. FACETS: 84 CLP: 80 | QALYs (EQ-5D), SF-6D | Health and social care | 4mths | |
Age in years (mean, SD): | FACETS: 48 (10.2) CLP: 50.1 (9.1) | GBP (2010) | ||||||||
Sex (% female): | 73 | |||||||||
Ethnicity (% white): | FACETS: 94 CLP: 99 |