Table 4 The evaluation of additive interaction for the prevention of therapeutic duplication or drug interaction
Variables | Levels | Non-user | User | aARDs of product terms (95% CIs) |
|---|---|---|---|---|
Age | < 60 years | REF | 2.1 | -0.8 (-4.4 to 2.8) |
≥ 60 years | 0.5 | 1.8 | ||
Sex | Male | REF | -0.2 | 4.7 (1.6 to 7.9) |
Female | 0.5 | 5.1 | ||
Types of drugs | < 6 | REF | -1.0 | 4.4 (1.7 to 7.1) |
≥ 6 | 0.0 | 3.4 | ||
Medical institutions used | < 2 | REF | -0.9 | 4.5 (1.8 to 7.3) |
≥ 2 | -0.1 | 3.5 | ||
Use of multiple departments in a hospital | No | REF | 1.4 | 7.0 (-0.5 to 14.5) |
Yes | 2.2 | 10.6 | ||
Admission | No | REF | 1.7 | 4.1 (-4.2 to 12.4) |
Yes | 0.5 | 6.2 | ||
Use of one-dose package for drugs | No | REF | 1.6 | 5.9 (-2.4 to 14.1) |
Yes | 1.8 | 9.2 | ||
Antihypertensives | No | REF | 1.7 | 0.5 (-2.8 to 3.7) |
Yes | 0.0 | 2.2 | ||
Antilipidemic agents | No | REF | 2.2 | -1.3 (-4.6 to 2.1) |
Yes | 0.4 | 1.4 | ||
Antidiabetic agents other than insulin | No | REF | 1.6 | 2.6 (-2.7 to 7.9) |
Yes | 0.6 | 4.7 | ||
Insulin | No | REF | 1.6 | 14.6 (-1.6 to 30.8) |
Yes | 1.1 | 17.3 | ||
Anticoagulants | No | REF | 1.7 | 6.0 (-6.9 to 18.9) |
Yes | 0.5 | 8.2 | ||
Antiplatelet agents | No | REF | 1.9 | 0.4 (-7.4 to 8.1) |
Yes | -0.3 | 2.0 | ||
Proton pump inhibitors | No | REF | 1.1 | 5.8 (0.7 to 10.8) |
Yes | 1.7 | 8.6 | ||
H2 blockers | No | REF | 1.8 | 0.7 (-5.7 to 7.0) |
Yes | 1.4 | 3.9 | ||
H1 blockers | No | REF | 0.9 | 3.1 (-0.3 to 6.6) |
Yes | 0.7 | 4.7 | ||
Antipsychotics | No | REF | 1.6 | 2.3 (-3.1 to 7.7) |
Yes | 0.4 | 4.3 | ||
BZDs/Non-BZDs | No | REF | 1.1 | 3.6 (-0.5 to 7.7) |
Yes | 0.5 | 5.2 | ||
Antidepressants | No | REF | 2.0 | -0.9 (-5.4 to 3.7) |
Yes | 0.0 | 1.1 | ||
Antibiotics | No | REF | 0.0 | 5.5 (2.0 to 9.0) |
Yes | 0.0 | 5.6 | ||
NSAIDs | No | REF | 1.5 | 1.0 (-2.2 to 4.3) |
Yes | 0.3 | 2.8 | ||
Steroids | No | REF | 1.4 | 5.0 (-1.2 to 11.1) |
Yes | 0.8 | 7.1 | ||
Probiotics | No | REF | 0.8 | 8.0 (2.4 to 13.5) |
Yes | 0.3 | 9.1 | ||
Laxatives | No | REF | 1.7 | 3.6 (-4.2 to 11.3) |
Yes | 0.4 | 5.7 | ||
Vitamins | No | REF | 1.7 | 2.4 (-3.4 to 8.1) |
Yes | 0.7 | 4.7 | ||
Traditional Japanese herbal medicines | No | REF | 0.5 | 7.0 (2.5 to 11.5) |
Yes | 0.5 | 8.0 |