Table 3 The evaluation of additive interaction for the adjustment of leftover drugs
Variables | Levels | Non-user | User | aARDs of product terms (95% CIs) |
|---|---|---|---|---|
Age | < 60 years | REF | 2.2 | -1.5 (-4.8 to 1.8) |
≥ 60 years | 1.1 | 1.7 | ||
Sex | Male | REF | 2.5 | -1.2 (-3.8 to 1.5) |
Female | 0.1 | 1.4 | ||
Types of drugs | < 6 | REF | 2.1 | -0.2 (-3.1 to 2.6) |
≥ 6 | 0.3 | 2.1 | ||
Medical institutions used | < 2 | REF | 2.3 | -0.6 (-3.4 to 2.1) |
≥ 2 | -0.2 | 1.4 | ||
Use of multiple departments in a hospital | No | REF | 1.9 | 0.6 (-5.0 to 6.1) |
Yes | 1.0 | 3.4 | ||
Admission | No | REF | 1.7 | 6.3 (-2.3 to 14.9) |
Yes | 0.3 | 8.3 | ||
Use of one-dose package for drugs | No | REF | 1.8 | 3.8 (-3.9 to 11.6) |
Yes | 3.2 | 8.8 | ||
Antihypertensives | No | REF | 1.6 | 1.0 (-2.0 to 3.9) |
Yes | 1.0 | 3.5 | ||
Antilipidemic agents | No | REF | 2.5 | -2.0 (-5.2 to 1.2) |
Yes | 1.2 | 1.6 | ||
Antidiabetic agents other than insulin | No | REF | 1.9 | -0.7 (-5.8 to 4.5) |
Yes | 3.8 | 5.1 | ||
Insulin | No | REF | 1.7 | 14.3 (-1.6 to 30.2) |
Yes | 1.6 | 17.6 | ||
Anticoagulants | No | REF | 1.9 | -0.4 (-9.8 to 9.0) |
Yes | 2.1 | 3.5 | ||
Antiplatelet agents | No | REF | 2.0 | -2.0 (-8.7 to 4.7) |
Yes | 1.7 | 1.6 | ||
Proton pump inhibitors | No | REF | 1.7 | 1.7 (-2.5 to 5.8) |
Yes | 1.2 | 4.6 | ||
H2 blockers | No | REF | 2.0 | -1.7 (-6.5 to 3.1) |
Yes | 0.3 | 0.6 | ||
H1 blockers | No | REF | 1.7 | 0.4 (-2.4 to 3.2) |
Yes | 0.1 | 2.3 | ||
Antipsychotics | No | REF | 1.6 | 3.5 (-1.8 to 8.9) |
Yes | 0.8 | 5.9 | ||
BZDs/Non-BZDs | No | REF | 1.4 | 2.3 (-1.2 to 5.8) |
Yes | 0.5 | 4.2 | ||
Antidepressants | No | REF | 1.3 | 5.2 (0.01 to 10.3) |
Yes | 0.5 | 7.0 | ||
Antibiotics | No | REF | 2.1 | -0.5 (-3.3 to 2.2) |
Yes | -0.1 | 1.5 | ||
NSAIDs | No | REF | 2.5 | -1.8 (-4.5 to 0.9) |
Yes | 0.1 | 0.8 | ||
Steroids | No | REF | 2.0 | -1.0 (-5.2 to 3.2) |
Yes | 0.4 | 1.4 | ||
Probiotics | No | REF | 1.8 | 0.5 (-3.3 to 4.4) |
Yes | 0.1 | 2.4 | ||
Laxatives | No | REF | 1.9 | 0.3 (-5.7 to 6.2) |
Yes | 0.4 | 2.5 | ||
Vitamins | No | REF | 1.9 | 0.0 (-4.3 to 4.4) |
Yes | 0.2 | 2.2 | ||
Traditional Japanese herbal medicines | No | REF | 2.0 | -0.4 (-3.6 to 2.7) |
Yes | 0.3 | 1.9 |