Table 9 Results of the alternative scenario analysis
Brolucizumab (A) | Aflibercept (B) | Difference (A-B) | |
|---|---|---|---|
Outcomes | |||
Life years (LYs) | 9.00 | 9.00 | 0.00 |
Quality adjusted life years (QALYs) | 6.43 | 6.32 | 0.11 |
Direct and indirect costs (€) | |||
Treatment acquisition costs (€) | 46,821 | 58,265 | - 11,444 |
Treatment administration costs (€) | 15,130 | 17,277 | - 2147 |
Disease monitoring costs (€) | 1663 | 1895 | - 232 |
TREA management costs (€) | 115 | 47 | 68 |
Costs of blindness (€) | 17,386 | 18,582 | - 1196 |
Costs of low vision (€) | 10,539 | 13,725 | - 3186 |
Total costs (€) | 91,654 | 109,791 | −18,137 |
Incremental cost-effectiveness ratio (ICER) | |||
ICER (brolucizumab vs aflibercept) (€/QALY) | Brolucizumab dominant | ||