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Table 2 "4 + 7" drugs causing adverse reactions and their clinical manifestations

From: Reevaluation of adverse drug reactions of psychiatric drugs under the chinese drug volume-based procurement policy

Drugs

Case

Ratio (%)

Clinical manifestations (Case)

Olanzapine

54

39.42

Constipation (18) / Excessive sedation (6) / Extrapyramidal reactions (4) / Lower extremity edema (4) / Abnormal liver function (3) / Decreased blood pressure (3) / Dyslipidemia (2) / Sinus bradycardia (2) / Seizures (1) / Blurred vision (1) / Dry eyes (1) / Restlessness (1) / Prolonged QT interval (1) / Dry mouth (1) / Salivation (1) / Menstruation occurs two years after menopause (1) / Albumin reduction (1) / Hyperglycemia (1) / Allergic dermatitis (1) / Skin rash (1)

Clozapine

38

27.73

Constipation (17) / Salivation (6) / Sinus tachycardia (3) / Abnormal liver function (2) / Palpitation (1) / Epileptic seizures (1) / Akathisia (1) / Lethargy (1) / Incomplete intestinal obstruction (1) / decreased thyroid function (1) / Leukopenia (1) / Thrombocytopenia (1) / Increased blood concentration (1) / Frequent urination (1)

Risperidone

23

16.79

Extrapyramidal reactions (4) / Hyperprolactinemia (3) / Dizziness (2) / Leukopenia (2) / Akathisia (1) / Blurred vision (1) / drowsiness (1) / Excessive sedation (1) / Sinus bradycardia (1) / Sinus tachycardia (1) / Constipation (1) / Abnormal liver function (1) / Salivation (1) / Thrombocytopenia (1) / Urination difficulty (1) / Malignant syndrome (1)

Quetiapine

22

16.06

Constipation (4) / Leukopenia (3) / Abnormal liver function (3) / Excessive sedation (3) / Drowsiness (2) / Dizziness (1) / Dysphagia (1) / Dry mouth (1) / Hyperprolactinemia (1) / Lactation (1) / Asthenia (1) / Lower limb edema (1)

Total

137

100

 
  1. Note: Some drugs may involve multiple clinical manifestations of adverse reactions, so the number of specific adverse reactions was greater than the total number of reported cases