Evaluation of a Medicaid performance improvement project to reduce high-dose opioid prescriptions

Table 2 Results from interrupted time series regressions of opioid utilization and opioid overdose outcomes before and during performance improvement project

	Opioid prescriptions per 1000 enrollees per month			High-dose opioid prescriptions per 1000 enrollees per month			Proportion of opioid prescriptions that are high dose
	Coefficient	95% CI	p-value	Coefficient	95% CI	p-value	Coefficient	95% CI	p-value
Intercept	115.89	112.37 to 119.41	< 0.01	19.94	19.16 to 20.72	< 0.01	17.22	16.51 to 17.94	< 0.01
Baseline trend	−2.13	−2.61 to −1.65	< 0.01	−0.34	−0.43 to −0.25	< 0.01	0.03	−0.06 to 0.12	0.56
Immediate change	−1.07	−4.85 to 2.71	0.57	−1.55	− 2.26 to − 0.84	< 0.01	−1.29	− 1.94 to − 0.64	< 0.01
Trend change	1.29	0.80 to 1.79	< 0.01	0.06	−0.04 to 0.15	0.23	−0.23	− 0.33 to − 0.14	< 0.01

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