Table 2 Breakdown of the impact for Proposal 1. Assistance from multidisciplinary teams with all the relevant professionals involved

1.1. The satisfaction of adult HA patients concerning the SNHS would improve.

Number of adult HA patients who would improve their satisfaction with the SNHS: 1841 [49, 50].

Average annual premium per private insurance policyholder: €797.86 [51].

Percentage of adult patients with haemophilia seen annually by nursing staff: 46.00% [52].

Percentage of the impact ascribed to returns 1.1, 2.4, 4.3 and 5.5: 40.00%.

€475,805

1.2. The empowerment and quality of life of patients with HA would improve, thanks to access to social work services.

Number of patients with HA who would be more empowered, thanks to access to social work services: 1298 [49, 53].

Cost of five family therapy sessions: €441.51 [54].

Percentage of haemophilia patients seen annually by social work: 10.74% [52].

N/A

€511,343

1.3. Oral bleeding would be avoided in patients with HA, thanks to access to dental services.

Number of patients with HA in whom the appearance of dental caries would be avoided: 1298 [49, 53].

Total cost per person associated with the burden of dental disease: €171.96 [55].

Percentage of patients with HA who are already being cared for by a dentist: 50.00% [53].

N/A

€111,559

1.4. The function and quality of life of patients with HA and arthropathy would be improved, thanks to access to rehabilitation/physiotherapy and orthopaedic surgery services.

Total number of Quality-Adjusted Life Years (QALY) that would be maintained when attended by a rehabilitation/physiotherapy or orthopaedic surgery professional: 52 [8, 49, 53].

Incremental cost-effectiveness threshold per QALY: €21,000.00 [56].

Percentage of patients with HA and arthropathy who are already being cared for by an orthopaedic surgery professional: 50.00% [53].

N/A

€544,950

1.5 The function and quality of life of patients with HA and obesity or overweight would be improved, thanks to access to diet and nutrition services

Total number of QALYs that would be gained from being cared for by a dietetic and nutrition professional: 34 [5, 49, 53, 57].

Incremental cost-effectiveness threshold per QALY: €21,000.00 [56].

Percentage of HA patients with obesity or overweight who are already being cared for by a professional in dietetics and nutrition: 50.00% [53].

N/A

€355,600

1.6 The quality of life of patients with HA and mental health disorders would be improved, thanks to access to psychology services

Total number of QALYs that would be gained by being cared for by a professional in psychology: 92 [5, 49, 53, 58].

Incremental cost-effectiveness threshold per QALY: €21,000.00 [56].

Percentage of patients with haemophilia seen annually by psychology: 15.73% [52].

N/A

€1,627,800

1.7. The satisfaction of informal caregivers of patients with HA concerning the SNHS would improve.

Number of informal caregivers of patients with HA who would improve their satisfaction with the SNHS: 969 [49, 50, 53].

Average annual premium per private insurance policyholder: €797.86 [51].

Percentage of patients with haemophilia seen annually by nursing staff: 51.73% [52].

Percentage of the impact ascribed to returns 1.7, 2.6, 4.4 and 5.7: 40.00%.

€223,985