Characteristic | Low-Dose (n = 482) | Full-Dose (n = 25,664) | Adjusted Odds Ratioa to Receive Low-dose DOAC | 95% Confidence Interval | p-value |
---|---|---|---|---|---|
Age (yrs) | |||||
 ≤ 69 | 18.0% | 55.7% | REF |  |  |
 70–74 | 10.4% | 20.5% | 1.43 | (0.98, 2.06) | 0.06 |
 75–79 | 9.5% | 10.8% | 1.81 | (1.20, 2.69) | 0.004 |
 >  80 | 62.0% | 12.9% | 6.41 | (4.68, 8.84) | <  0.001 |
Gender | |||||
 Female | 2.7% | 1.6% | 1.38 | (0.68, 2.55) | 0.34 |
 Male | 97.3% | 98.4% | REF |  |  |
Race | |||||
 White | 85.3% | 86.6% | REF |  |  |
 Black | 7.7% | 7.2% | 1.28 | (0.86, 1.87) | 0.21 |
 Other | 7.1% | 6.2% | 1.06 | (0.68, 1.59) | 0.80 |
Geographic Region | |||||
 Northeast | 12.0% | 12.7% | REF |  |  |
 Midwest | 21.4% | 23.9% | 1.19 | (0.83, 1.72) | 0.34 |
 West | 21.0% | 23.8% | 1.25 | (0.88, 1.81) | 0.22 |
 South | 45.6% | 39.6% | 1.59 | (1.16, 2.21) | 0.004 |
BMI (kg/m2) | |||||
 <  25 | 28.4% | 14.6% | REF |  |  |
 25–29.9 | 35.7% | 30.6% | 1.32 | (1.02, 1.73) | 0.04 |
 30–34.9 | 21.4% | 27.5% | 1.80 | (1.31, 2.46) | <  0.001 |
 ≥ 35 | 11.2% | 25.8% | 1.52 | (1.02, 2.26) | 0.04 |
Key Comorbid Conditionsb | |||||
 Heart Failure | 20.3% | 13.6% | 1.36 | (1.03, 1.79) | 0.03 |
 Hypertension | 77.8% | 71.6% | 1.09 | (0.83, 1.44) | 0.55 |
 Vascular Disease | 15.4% | 13.2% | 1.15 | (0.86, 1.53) | 0.34 |
 Diabetes | 44.2% | 41.4% | 1.24 | (0.98, 1.57) | 0.07 |
 Prior Bleeding | 4.6% | 3.1% | 1.20 | (0.73, 1.90) | 0.45 |
 Stroke | 8.3% | 5.9% | 1.04 | (0.71, 1.47) | 0.85 |
eGFR Categories (%), in units of mL/min/1.73 m2 | |||||
 30–39 | 28.0% | 1.9% | 18.16 | (13.05, 25.27) | <  0.001 |
 40–49 | 23.7% | 4.6% | 6.96 | (5.05, 9.58) | <  0.001 |
 50–59 | 17.4% | 7.9% | 3.36 | (2.42, 4.64) | <  0.001 |
 >  60 | 30.9% | 85.6% | REF |  |  |
Elixhauser Comorbidities | |||||
 0–2 | 25.9% | 30.0% | REF |  |  |
 3–4 | 34.6% | 39.1% | 0.94 | (0.71, 1.26) | 0.69 |
 ≥ 5 | 30.5% | 25.1% | 1.35 | (0.95, 1.91) | 0.10 |