Table 1 Input parameters for estimating the economic burden of ADRs
Input variable | Base case | Sensitivity analysis | |||
|---|---|---|---|---|---|
Value | Explanation/reference | One way | Probabilistic | Note | |
Employment rate | 75% | StatCan. Average employment rate for 19–65 years old for the respective years | – | 64–83% | Random selection employed or unemployed with a rough mean of 75% (applied at the population level) |
Average Income | $37,847 $54,690 $46,268 | Average individual incomes for female, male, sex-unknown individuals adjusted to 2018 $. Source: StatCan | – | $40,343–$61,181 | Gamma distribution (applied at patient level) - the range is for the population average |
Discount rate | 1.5% | CADTH recommendation | 0–3% | Not performed | |
Friction time | 3 months | Conventional | 1–5 months | Not performed | |
Loss of employment due to disability | 22.5% | StatCan. For mild disability conditions, the employment rate is 7% lower, and for severe disability conditions, the employment is 33% lower. The average was assumed for the base case | – | 15–32% | Random selection employment loss from disability with a rough mean of 22.5% (applied at the population level) |
Average loss of income due to disability | 31.5% | StatCan. For mild disability conditions, the average loss of income is 12% and for severe disability conditions, the loss is 51%. The average was assumed for the base case | – | 29–34% | Gamma distribution (applied at patient level) - the range provided here is population average |
Annual disability payment | $11,506 | CPP average disability benefit 2018 value | – | Not performed | |
Cost per hospitalization | $1766–$5325 ($4205) | CIHI. Average annual cost for various age groups adjusted to 2018 $ (population average) | – | $4338–$4882 | Gamma distribution (applied at patient level) - the range provided here is population average |
Length of stay hospitalization | 1.2–3.9 days (2.3 days) | CIHI average length of stay for various age groups (population average) | – | 2.6–2.9 days | Gamma distribution (applied at patient level) - the range provided here is population average |
Cost of treatment of other medically important condition | $417 | Average cost for an ER visit in Alberta in 2018 | $208–$626 | – | |