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Table 2 Indirect costs of SSTI (Euroa)

From: Indirect costs associated with skin infectious disease in children: a systematic review

First Author-Country and Date

Sample Size

Subgroup

Daily school cost, €a

Avg. daily wage per parent, €a

Avg. No. school days lost per patient

Avg. No. workdays lost per patient

Total cost school days lost, €a

Total cost productivity loss, €a

Total hospital indirect cost, €a

Total annual indirect cost (all cases), €a, b

Total indirect cost reduction for vaccination, €a

Avg. cost nanny per child and process, €a

Bacterial infection

 Lee-USA-2013 [8]

NA

      

1,814.39–8,224.06

    

 Rice-USA-1992 [28]

93

 

29.49

78.79/day

        
  

Erythromycin

  

3.0 ± 3.5

0.5 ± 0.8

79.46 ± 92.70

39.33 ± 59.74

    
  

Mupirocin

  

1.2 ± 1.7

0.2 ± 0.7

31.78 ± 45.03

14.93 ± 52.27

    

 Wright-USA-2013 [6]

344

–

          
  

TP

   

2 (IQR 1-2)

  

1,824.54c

   
  

MI

   

1 (IQR 1–1.25)

  

1,529.96c

   

Viral infection

 Díez-Domingo- ESP-2003 [10]

683

  

84.55/day

6.22 ± 5.29

0.97 (0.5–15)

 

82.01 (42.27–1,268.23)

   

11.95

 Ferson-AUS1998 [29]

174

          

19.61

  

Mother

 

94.89/day

 

2.5 (95% CI:2.0–2.9)

 

234.34

    
  

Father

 

113.89/day

 

0.42 (95% CI:0.26–0.58)

 

47.83

    

 Giglio-ARG-2018 [30]

150

        

17,382,154.02

  
  

Outpatients

   

7.8

 

141.91

    
  

Inpatients

   

4.8

 

98.17

    

 Hsu-TWN-2003 [25]

NA

  

51.08/day

 

1.85

 

94.5

  

31.66 mill (all cases)

 

 Lieu-USA-1994 [31]

179

      

210.55 e

   

52.12 (10.42-312.70) d

  

Mother

   

2.5

 

257.46

    
  

Father

   

0.8

 

174.07

    

 Meszner-HUN-2017 [33]

156

        

4,308,232.09

  
  

Outpatients

   

2.5

 

114.21

    
  

Inpatients

   

3.6

 

191.76

    

 Scuffham-NZL-1999 [27]

NA

  

38.61/day

      

70.60 (per vaccinated child)

 
  

Outpatients

   

3

 

115.84

    
  

Inpatients

   

6.14

 

237.08

    

 Valentim-BRA-2008 [26]]

156

           
  

Outpatients

   

0.27

 

1.16

    
  

Inpatients

   

4.78–4.84

 

20.61–20.87

    

 Wysocki-POL-2018 [32]

150

        

34,623,835.89

  
  

Outpatients

   

2.7

 

201.03

    
  

Inpatients

   

4.7

 

251.71

    

Parasitic infestation

 Gur USA-2009 [14]

NA

  

21.41/h

1

0.04

 

21.41

   

68.57

  1. aCost in Euros adjusted to 2020 Euros. bBased in the annual number of cases of VZV infection for 2015: n = 133,434 [29]; n = 172,117 [31]; n = 37,585 [32]. cSignificant differences between traditional packing and minimally invasive treatment (p < 0.001). d Value corresponds to median.; e Average cost for productivity loss per child. Avg Average, CI Confidence interval, IQR Interquartile range, MI Minimally invasive treatment, NA Not applicable, No Numbers, TP Traditional packing treatment. Total annual indirect cost considers the total number of infections in the season and includes indirect costs derived from productivity loss. Total cost productivity loss refers to costs due to work absence or loss of productivity
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