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Table 1 Model parameters: Probabilities of occurrence of events, costs and utilities

From: Cost-utility of two minimally-invasive surgical techniques for operable oropharyngeal cancer: transoral robotic surgery versus transoral laser microsurgery

Variable name

Description

Mean

Standard deviation

Distribution type

Parameter 1 (alpha)

Parameter 2 (beta)

Probabilities of events

 pes

Probability of esophageal stenosis

0.0476

0.0005

Beta

4

80

 phem

Probability of hemorrhage

0.0243

0.0001

Beta

6

241

 pho_adj

Probability of hospital readmission after adjuvant

0.1731

0.0027

Beta

9

43

 pho_s

Probability of hospital readmission (TORS or TLM)

0.0333

0.0010

Beta

1

29

 plg

Probability of long-term gastrostomy (1 year) after adjuvant treatment

0.0500

0.0003

Beta

9

171

 plt

Probability of long-term tracheostomy (1 year)

0.0226

0.0001

Beta

4

173

 psg

Probability of short-term (6 months) gastrostomy (TORS or TLM)

0.0144

0.0001

Beta

2

137

 psg_adj

Probability of short-term (6 months) gastrostomy after adjuvant

0.2991

0.0019

Beta

32

75

 por

Probability of osteoradionecrosis

0.0265

0.0002

Beta

4

147

 ppf

Probability of pharyngocutaneous fistula

0.0253

0.0001

Beta

10

385

 pTLMAlone

Probability of TLM alone

0.4085

0.0007

Beta

134

194

 pTorsAlone

Probability of TORS alone

0.3740

0.0001

Beta

824

1379

 pCRT_TLM

Probability of adjuvant CRT (TLM)

0.6289

0.0012

Beta

122

72

 pCRT_tors

Probability of adjuvant CRT (TORS)

0.5272

0.0002

Beta

727

652

 pRT_TLM

Probability of adjuvant RT (TLM)

0.3711

0.0012

Beta

72

122

 pRT_tors

Probability of adjuvant RT (TORS)

0.4728

0.0002

Beta

652

727

 plra

Probability of local or regional recurrence (first 2 years)

0.0064

0.0000

Beta

11

1715

 prra

Probability of regional recurrence (first 2 years)

0.0064

0.0000

Beta

11

1715

 pdra

Probability of distant recurrence (first 2 years)

0.0038

0.0000

Beta

11

2900

Costs (CHF)

 cTORS

Cost of TORS

14,739

869.31

Gamma

287.4635

0.0195

 cTLM

Cost of TLM

12,671

516.23

Gamma

602.4698

0.0475

 cCRT

Cost of adjuvant CRT

33,911

2079.08

Gamma

266.0350

0.0078

 cRT

Cost of adjuvant RT

27,962

1714.35

Gamma

266.0342

0.0095

 cES

Cost of esophageal stenosis

2362

410.65

Gamma

33.0832

0.0140

 cGAST

Cost of gastrostomy

4332

410.65

Gamma

111.2820

0.0257

 cHR_adj

Cost of hospital readmission (for adjuvant)

10,097

619.05

Gamma

266.0342

0.0263

 cHR_s

Cost of hospital readmission (TORS or TLM)

8203

803.41

Gamma

104.2498

0.0127

 cORN

Cost of osteoradionecrosis

32,111

1077.71

Gamma

887.7769

0.0276

 cPF

Cost of pharyngocutaneous fistula

82,892

333.96

Gamma

61,609.3654

0.7432

 cPH

Cost of hemorrhage (from surgical site)

4469

415.50

Gamma

115.6865

0.0259

 cTRACH

Cost of tracheostomy

11,688

612.67

Gamma

363.9366

0.0311

 cREM

Cost of remission 0–2 y

168.5

9.68

Gamma

303.2588

1.7998

 c2REM

Cost of remission 2–5 y

60

9.68

Gamma

38.4518

0.6409

 cPC

Cost of palliative care

4137

367.86

Gamma

126.4754

0.0306

 cRR

Cost of regional recurrence

7047

464.24

Gamma

230.4227

0.0327

 cLR_chemorad

Cost of local recurrence (chemoradiation)

34,041

2079.08

Gamma

268.0786

0.0079

 cLR_s

Cost of local recurrence (surgical resection)

40,513

2050.27

Gamma

390.4511

0.0096

 cDM

Cost of distant metastasis

4137

367.86

Gamma

126.4754

0.0306

 cPanendo

Cost of panendoscopy

388

23.79

Gamma

266.0337

0.6857

Utilities

 uSURG

Utility coefficient of TORS or TLM

0.902

0.203

Beta

1.0328

0.1122

 uRT

Utility coefficient of adjuvant RT

0.850

0.275

Beta

0.5831

0.1029

 uCRT

Utility coefficient of adjuvant CRT

0.794

0.317

Beta

0.4984

0.1293

 uHR

Utility coefficient of hospital readmission

0.954

0.140

Beta

1.1820

0.0570

 uPF

Utility coefficient of pharyngocutaneous fistula

0.932

0.194

Beta

0.6374

0.0465

 uPH

Utility coefficient of postoperative hemorrhage

0.910

0.203

Beta

0.8986

0.0889

 Ug

Utility coefficient of gastrostomy

0.916

0.209

Beta

0.6975

0.0640

 Ult

Utility coefficient of long-term tracheostomy

0.852

0.271

Beta

0.6109

0.1061

 ues

Utility coefficient of esophageal stenosis

0.826

0.284

Beta

0.6459

0.1361

 uORN

Utility coefficient of osteoradionecrosis

0.791

0.302

Beta

0.6428

0.1698

 urem

Utility coefficient of remission after surgery and adjuvant

0.980

0.099

Beta

0.7702

0.0346

 uremonlysurg

Utility coefficient of remission after TORS or TLM alone

0.957

0.151

Beta

0.9798

0.0200

 ureg

Utility coefficient of regional recurrence

0.859

0.283

Beta

0.4401

0.0722

 ulocxrt

Utility coefficient of local recurrence, RT

0.771

0.302

Beta

0.7216

0.2143

 uloc

Utility coefficient of local recurrence, requiring surgery

0.755

0.316

Beta

0.6436

0.2088

 udist

Utility coefficient of distant recurrence

0.213

0.336

Beta

0.2262

0.5106

 upall

Utility coefficient of palliative care

0.307

0.350

Beta

0.1033

0.3816

  1. aNOTE: for prr, plr and pdr 80% of recurrences were modeled in the first 2 years, and the remaining 20% between 2 and 5 years posttreatment (probabilities were adjusted accordingly, assuming 5% of patients have recurrences in the first 2 years6)