Type of Cost | Warfarin mean ± S.D. | 95% CI | DOAC mean ± S.D. | 95% CI | Cost difference (Warf - DOAC) | p-value |
---|---|---|---|---|---|---|
AF-related total cost for healthcare | 805.2 ± 1118.7 | 766.3–844.1 | 927.3 ± 1150.9 | 849.0–1005.6 | − 122.1 | 0.006 |
AF-related total cost for patient | 296.7 ± 256.3 | 287.8–305.6 | 406.5 ± 132.8 | 397.5–415.5 | −109.8 | < 0.001 |
AF-related total cost (patient + healthcare) | 1102.0 ± 1272.2 | 1057.7–1146.3 | 1333.8 ± 1250.8 | 1248.7–1418.9 | −231.8 | < 0.001 |
Patient costs | ||||||
Patient’s time and travel cost | 195.6 ± 221.8 | 187.9–203.3 | 17.5 ± 61.5 | 13.3–21.7 | 178.1 | < 0.001 |
Patient’s time cost | 79.5 ± 84.4 | 76.6–82.4 | 3.3 ± 11.2 | 2.5–4.1 | 76.2 | < 0.001 |
Patient’s travel cost | 118.2 ± 168.1 | 112.3–124.1 | 14.3 ± 52.4 | 10.7–17.9 | 103.9 | < 0.001 |
Healthcare fees for patient | 74.0 ± 155.0 | 68.6–79.4 | 29.2 ± 88.0 | 23.2–35.2 | 44.8 | < 0.001 |
Drug cost for patient | 27.0 ± 0.0 | 27.0–27.0 | 359.8 ± 10.4 | 359.1–360.5 | − 332.8 | < 0.001 |
Healthcare costs | ||||||
INR monitoring cost | 519.2 ± 296.2 | 508.9–529.5 | 4.3 ± 14.1 | 3.3–5.3 | 514.9 | < 0.001 |
Primary healthcare visit costs | 12.7 ± 51.7 | 10.9–14.5 | 16.6 ± 47.5 | 13.4–19.8 | −3.9 | 0.042 |
Specialised healthcare visit costs | 61.1 ± 303.9 | 50.5–71.7 | 100.3 ± 608.5 | 58.9–141.7 | −39.2 | 0.072 |
Ward costs in primary healthcare | 12.2 ± 130.2 | 10.9–14.5 | 13.9 ± 122.4 | 5.6–22.2 | −1.7 | 0.731 |
Ward costs in specialised healthcare | 78.6 ± 706.7 | 54.0–103.2 | 88.4 ± 781.0 | 35.2–141.6 | −9.8 | 0.743 |
Drug cost for society | 18.0 ± 0.0 | 18.0–18.0 | 668.2 ± 19.4 | 666.9–669.5 | − 650.2 | < 0.001 |
Kela’s travel cost for society | 99.3 ± 305.4 | 88.7–109.9 | 26.5 ± 110.8 | 19.0–34.0 | 72.8 | < 0.001 |