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Table 3 Quality assessment results of evidence used based on the hierarchy of data sources by Cooper et al. [12]

From: Pharmacogenetic testing for adverse drug reaction prevention: systematic review of economic evaluations and the appraisal of quality matters for clinical practice and implementation

Input parameters

Hierarchy of data sources

% Agreement*

1

2

3

4

5

6

9

#

Clinical effect sizes

16 (27%)

0

0

29 (49%)

0

2 (3%)

4 (7%)

8 (14%)

85

Baseline clinical data

4 (7%)

1 (2%)

0

51 (85%)

1 (2%)

1 (2%)

1 (2%)

 

81

Resource use

7 (12%)

51 (86%)

0

0

0

1 (2%)

0

 

92

Costs

6(10%)

53 (90%)

0

0

0

0

0

 

85

Utility

2(5%)

0

38 (93%)

1 (2%)

0

0

0

 

97

  1. # Meta-analysis of case-control with direct comparison between comparator therapies and measuring final outcomes
  2. *Percentage of agreement between two independent raters