Table 4 Impact of MDTMs on survival
Overall survival - HR (CI) n = 3472 | Excluding patients dying within 3 months after diagnosis - HR (CI) n = 3194 | |||
|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |
Presentation in MDTMs | p < 0.001 | p < 0.001 | p < 0.001 | p = 0.005 |
Yes | 1 | 1 | 1 | 1 |
No | 3.5 (3.0–4.2) | 2.8 (2.4–3.4) | 1.7 (1.3–2.3) | 1.5 (1.1–2.0) |
Sex | p = 0.16 | p = 0.16 | p = 0.63 | p = 0.14 |
Male | 1 | 1 | 1 | 1 |
Female | 1.1 (1.0–1.2) | 0.9 (0.9–1.0) | 1.0 (0.9–1.1) | 0.9 (0.8–1.0) |
Age at diagnosis (year) | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 |
≤50 | 1 | 1 | 1 | 1 |
[51–65] | 1.0 (0.8–1.2) | 1.1 (0.8–1.3) | 1.0 (0.8–1.2) | 1.1 (0.8–1.3) |
[66–75] | 1.3 (1.1–1.7) | 1.5 (1.2–1.9) | 1.3 (1.0–1.6) | 1.5 (1.2–1.9) |
[76–80] | 1.9 (1.5–2.5) | 2.3 (1.8–2.9) | 1.9 (1.5–2.4) | 2.3 (1.8–3.0) |
> 80 | 3.2 (2.5–3.9) | 3.9 (3.1–4.8) | 2.9 (2.3–3.6) | 3.9 (3.1–4.9) |
Tumour localisation | p = 0.17 | p = 0.005 | p = 0.95 | p < 0.001 |
Colon | 1 | 1 | 1 | 1 |
Rectal | 0.9 (0.9–1.0) | 1.2 (1.0–1.3) | 1.0 (0.9–1.1) | 1.2 (1.1–1.3) |
Metastasis | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 |
Yes | 4.3 (3.9–4.7) | 5.5 (5.0–6.0) | 4.4 (4.0–4.8) | 5.7 (5.1–6.3) |
No | 1 | 1 | 1 | 1 |
Unknown | 5.7 (4.2–7.8) | 2.8 (2.1–3.9) | 3.9 (2.5–5.8) | 2.4 (1.6–3.7) |
Charlson Comorbidity Index | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 |
0 | 1 | 1 | 1 | 1 |
1 | 1.5 (1.3–1.7) | 1.3 (1.1–1.4) | 1.5 (1.3–1.6) | 1.3 (1.1–1.4) |
> 1 | 1.9 (1.7–2.2) | 1.7 (1.6–1.9) | 1.9 (1.7–2.1) | 1.8 (1.6–2.0) |
Unknown | 1.1 (0.9–1.3) | 1.0 (0.9–1.2) | 1.0 (0.8–1.2) | 1 .0 (0.8–1.2) |
Travel time quintiles (min) | p = 0.60 | p = 0.66 | p = 0.82 | p = 0.74 |
Q1 [3–10] | 1 | 1 | 1 | 1 |
Q2 [11–17] | 1.0 (0.8–1.1) | 1.0 (0.9–1.2) | 1.0 (0.9–1.1) | 1.1 (0.9–1.2) |
Q3 [18–28] | 1.0 (0.9–1.2) | 1.0 (0.9–1.2) | 1.0 (0.9–1.2) | 1.0 (0.9–1.2) |
Q4 [29–39] | 1.1 (0.9–1.2) | 1.1 (0.9–1.2) | 1.1 (0.9–1.2) | 1.1 (0.9–1.2) |
Q5 [40–75] | 1.0 (0.9–1.2) | 1.0 (0.8–1.1) | 1.1 (0.9–1.2) | 1.0 (0.8–1.1) |
European Deprivation Index quintiles | p < 0.001 | p = 0.27 | p < 0.001 | p = 0.14 |
Q1 (less deprived) | 1 | 1 | 1 | 1 |
Q2 | 1.0 (0.9–1.2) | 1.0 (0.8–1.1) | 1.0 (0.9–1.2) | 1.0 (0.9–1.2) |
Q3 | 1.1 (1.0–1.3) | 1.0 (0.8–1.1) | 1.1 (0.9–1.2) | 1.0 (0.8–1.1) |
Q4 | 1.3 (1.1–1.5) | 1.1 (0.9–1.3) | 1.3 (1.1–1.5) | 1.1 (1.0–1.3) |
Q5 (most deprived) | 1.3 (1.1–1.4) | 1.1 (0.9–1.3) | 1.3 (1.1–1.5) | 1.1 (1.0–1.3) |