Data Input Parameter | Value (range) | Distribution | Ref. |
---|---|---|---|
% of patients not requiring supplemental oxygen | 13% | Point estimate | [10] |
% of patients requiring supplemental oxygen | 42% | Point estimate | [10] |
% of patients receiving noninvasive ventilation | 18.2% | Point estimate | [10] |
% of patients receiving invasive ventilation or ECMO | 26.8% | Point estimate | [10] |
Prob. to die if hospitalized without supplemental oxygen | 4.8% (1.6-14.3) | Beta(1.427,29.02) | [10] |
Prob. to die if hospitalized with oxygen | 12.7% (8.8-18.3) | Beta(21.05,143.41) | [10] |
Prob. to die if receiving noninvasive ventilation | 20.4%(13.7-29.8) | Beta(17.03,65.94) | [10] |
Prob. to die if in ECMO | 19.3% (13.8-26.5) | Beta(24.51,102.92) | [10] |
Remdesivir Rate Ratio for time to recovery | 1.29 (1.21-1.49) | LogN(0.255, 0.0735) | [10] |
Remdesivir Hazard Mortality Ratio | 0.91 | Point Estimate | [12] |
(only for the alternative scenario) | Â | Â | Â |
Dexamethasone HMR for hospitalized with supplemental oxygen | 0.82 (.72-.94) | LogN(-.198, 0.07) | [18] |
Dexamethasone HMR for ventilated patients (invasive and non invasive) | 0.64 (.51-.81) | LogN(-.446, 0.12) | [18] |
Days of hospitalization without supplemental oxygen | 6 (4-7) | Triangular | [10] |
Days of hospitalization with supplemental oxygen | 9 (7-10) | Triangular | [10] |
Days of hospitalization receiving noninvasive ventilation | 20 (14-26) | Triangular | [10] |
Days of hospitalization receiving invasive ventilation or ECMO | 28 (24-30) | Triangular | [10] |
Cost of Remdesivir | <DOLLAR/>2340 (1755-2925) | Gamma(2340, 305) | [14] |
Cost of Dexamethasone | <DOLLAR/>15 | Point estimate | [15] |
Total cost of hospitalization in standard care without supplemental oxygen | <DOLLAR/>9763 (7322 - 12203) | Gamma(9763, 1195) | [28] |
Total cost of hospitalization in standard care with supplemental oxygen | <DOLLAR/>13767 (10325 - 17208) | Gamma(13767, 1711) | [28] |
Total cost of hospitalization in standard care with non invasive ventilation | <DOLLAR/>34223 (25667 - 42778) | Gamma(34223,4113) | [28] |
Total cost of hospitalization in standard care with invasive ventilation or ECMO | <DOLLAR/>61169 (45876 - 76461) | Gamma(61169,7403) | [28] |
One year follow up costs for Covid-19 hospitalized survivors | <DOLLAR/>4132 (3099 - 5165) | Gamma(4132, 501) | [28] |
Utility for hospitalized patients without supplemental oxygen | 0.581(.472 -.729) | Beta(34.2, 23.97) | [30] |
Utility for hospitalized patients with supplemental oxygen | 0.5 (.4 -.6) | Beta(47.37, 47.37) | [30] |
Utility for hospitalized patients with non invasive ventilation | 0.23 (.18 -.23) | Beta(61.43, 207.97) | [31] |
Utility for hospitalized patients with invasive ventilation or ECMO | 0.05 (.02 -.08) | Beta(9.137, 171.78) | [32] |
Base Utility | 0.851 | Point Estimate | [33] |