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Table 1 Parameters of the model

From: Cost utility analysis of Remdesivir and Dexamethasone treatment for hospitalised COVID-19 patients - a hypothetical study

Data Input Parameter

Value (range)

Distribution

Ref.

% of patients not requiring supplemental oxygen

13%

Point estimate

[10]

% of patients requiring supplemental oxygen

42%

Point estimate

[10]

% of patients receiving noninvasive ventilation

18.2%

Point estimate

[10]

% of patients receiving invasive ventilation or ECMO

26.8%

Point estimate

[10]

Prob. to die if hospitalized without supplemental oxygen

4.8% (1.6-14.3)

Beta(1.427,29.02)

[10]

Prob. to die if hospitalized with oxygen

12.7% (8.8-18.3)

Beta(21.05,143.41)

[10]

Prob. to die if receiving noninvasive ventilation

20.4%(13.7-29.8)

Beta(17.03,65.94)

[10]

Prob. to die if in ECMO

19.3% (13.8-26.5)

Beta(24.51,102.92)

[10]

Remdesivir Rate Ratio for time to recovery

1.29 (1.21-1.49)

LogN(0.255, 0.0735)

[10]

Remdesivir Hazard Mortality Ratio

0.91

Point Estimate

[12]

(only for the alternative scenario)

   

Dexamethasone HMR for hospitalized with supplemental oxygen

0.82 (.72-.94)

LogN(-.198, 0.07)

[18]

Dexamethasone HMR for ventilated patients (invasive and non invasive)

0.64 (.51-.81)

LogN(-.446, 0.12)

[18]

Days of hospitalization without supplemental oxygen

6 (4-7)

Triangular

[10]

Days of hospitalization with supplemental oxygen

9 (7-10)

Triangular

[10]

Days of hospitalization receiving noninvasive ventilation

20 (14-26)

Triangular

[10]

Days of hospitalization receiving invasive ventilation or ECMO

28 (24-30)

Triangular

[10]

Cost of Remdesivir

<DOLLAR/>2340 (1755-2925)

Gamma(2340, 305)

[14]

Cost of Dexamethasone

<DOLLAR/>15

Point estimate

[15]

Total cost of hospitalization in standard care without supplemental oxygen

<DOLLAR/>9763 (7322 - 12203)

Gamma(9763, 1195)

[28]

Total cost of hospitalization in standard care with supplemental oxygen

<DOLLAR/>13767 (10325 - 17208)

Gamma(13767, 1711)

[28]

Total cost of hospitalization in standard care with non invasive ventilation

<DOLLAR/>34223 (25667 - 42778)

Gamma(34223,4113)

[28]

Total cost of hospitalization in standard care with invasive ventilation or ECMO

<DOLLAR/>61169 (45876 - 76461)

Gamma(61169,7403)

[28]

One year follow up costs for Covid-19 hospitalized survivors

<DOLLAR/>4132 (3099 - 5165)

Gamma(4132, 501)

[28]

Utility for hospitalized patients without supplemental oxygen

0.581(.472 -.729)

Beta(34.2, 23.97)

[30]

Utility for hospitalized patients with supplemental oxygen

0.5 (.4 -.6)

Beta(47.37, 47.37)

[30]

Utility for hospitalized patients with non invasive ventilation

0.23 (.18 -.23)

Beta(61.43, 207.97)

[31]

Utility for hospitalized patients with invasive ventilation or ECMO

0.05 (.02 -.08)

Beta(9.137, 171.78)

[32]

Base Utility

0.851

Point Estimate

[33]