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Table 1 Parameters of the model

From: Cost utility analysis of Remdesivir and Dexamethasone treatment for hospitalised COVID-19 patients - a hypothetical study

Data Input Parameter Value (range) Distribution Ref.
% of patients not requiring supplemental oxygen 13% Point estimate [10]
% of patients requiring supplemental oxygen 42% Point estimate [10]
% of patients receiving noninvasive ventilation 18.2% Point estimate [10]
% of patients receiving invasive ventilation or ECMO 26.8% Point estimate [10]
Prob. to die if hospitalized without supplemental oxygen 4.8% (1.6-14.3) Beta(1.427,29.02) [10]
Prob. to die if hospitalized with oxygen 12.7% (8.8-18.3) Beta(21.05,143.41) [10]
Prob. to die if receiving noninvasive ventilation 20.4%(13.7-29.8) Beta(17.03,65.94) [10]
Prob. to die if in ECMO 19.3% (13.8-26.5) Beta(24.51,102.92) [10]
Remdesivir Rate Ratio for time to recovery 1.29 (1.21-1.49) LogN(0.255, 0.0735) [10]
Remdesivir Hazard Mortality Ratio 0.91 Point Estimate [12]
(only for the alternative scenario)    
Dexamethasone HMR for hospitalized with supplemental oxygen 0.82 (.72-.94) LogN(-.198, 0.07) [18]
Dexamethasone HMR for ventilated patients (invasive and non invasive) 0.64 (.51-.81) LogN(-.446, 0.12) [18]
Days of hospitalization without supplemental oxygen 6 (4-7) Triangular [10]
Days of hospitalization with supplemental oxygen 9 (7-10) Triangular [10]
Days of hospitalization receiving noninvasive ventilation 20 (14-26) Triangular [10]
Days of hospitalization receiving invasive ventilation or ECMO 28 (24-30) Triangular [10]
Cost of Remdesivir <DOLLAR/>2340 (1755-2925) Gamma(2340, 305) [14]
Cost of Dexamethasone <DOLLAR/>15 Point estimate [15]
Total cost of hospitalization in standard care without supplemental oxygen <DOLLAR/>9763 (7322 - 12203) Gamma(9763, 1195) [28]
Total cost of hospitalization in standard care with supplemental oxygen <DOLLAR/>13767 (10325 - 17208) Gamma(13767, 1711) [28]
Total cost of hospitalization in standard care with non invasive ventilation <DOLLAR/>34223 (25667 - 42778) Gamma(34223,4113) [28]
Total cost of hospitalization in standard care with invasive ventilation or ECMO <DOLLAR/>61169 (45876 - 76461) Gamma(61169,7403) [28]
One year follow up costs for Covid-19 hospitalized survivors <DOLLAR/>4132 (3099 - 5165) Gamma(4132, 501) [28]
Utility for hospitalized patients without supplemental oxygen 0.581(.472 -.729) Beta(34.2, 23.97) [30]
Utility for hospitalized patients with supplemental oxygen 0.5 (.4 -.6) Beta(47.37, 47.37) [30]
Utility for hospitalized patients with non invasive ventilation 0.23 (.18 -.23) Beta(61.43, 207.97) [31]
Utility for hospitalized patients with invasive ventilation or ECMO 0.05 (.02 -.08) Beta(9.137, 171.78) [32]
Base Utility 0.851 Point Estimate [33]