Table 4 Factors associated with a divergent second medical opinion by multivariate logistic regression analysis

Class of diseases

 Oncology and hematological diseases

1 (Ref)

-

-

 Cardiovascular diseases

2.609

1.441

4.723

< 0.0001

 Reproductive diseases

1.746

0.923

3.303

 Skin disorders

1.356

0.483

3.808

 Digestive system diseases

1.759

0.867

3.570

 Endocrine and metabolic diseases

2.072

1.089

3.944

 Gynecological diseases

5.176

3.154

8.494

 Respiratory diseases

3.639

1.357

9.758

 Orthopedics and rhumatological diseases

1.266

0.860

1.864

 Nervous system and sensory organ diseases

1.267

0.761

2.11

 Urological diseases

4.246

2.053

8.782

Complexity

 Normal or common

1 (Ref)

-

-

< 0.0001

 Specific/exceptional

2.784

2.157

3.592

Time required for file review

0.985

0.959

1.011

0.26

Region of residence

 Ile-de-France

1 (Ref)

-

-

0.18

 Auvergne-Rhône-Alpes, Bourgogne-Franche-Comte

1.044

0.680

1.601

 Bretagne, Normandie, Pays de la Loire, Centre-Val de Loire

1.64

1.121

2.399

 Hauts-de-France, Grand Est

1.125

0.784

1.613

 Nouvelle-Aquitaine

0.98

0.583

1.647

 PACA, Occitanie

1.209

0.817

1.79

Professional status

 Intermediate profession

1 (Ref)

-

-

0.39

 Self-employed, business owner or manager

0.78

0.563

1.082

 Other

0.915

0.557

1.502

 Currently unemployed (job seekers or students)

0.813

0.499

1.323

 Manual labourer

0.944

0.449

1.983

 Retired

1.291

0.743

2.244

Age category

 Adult (36 to 50 years)

1 (Ref)

-

-

0.40

 Adult (19 to 35 years)

1.219

0.892

1.666

 Adult (51 to 65 years)

0.949

0.658

1.368

 Child (< 18 years)

1.211

0.654

2.24

 Older adult (66 to 80 years)

0.705

0.410

1.211

 Older adult (81 to 95 years)

0.573

0.185

1.771

 Sex Male (Ref = Female)

1.25

0.955

1.637

0.10