ICER tornado diagram for Strategy 4 vs Strategy 1 (top 10 drivers). Abbreviations: ICER, incremental cost-effectiveness ratio; MRI, magnetic resonance imaging; mpMRI, multi-parametric magnetic resonance imaging; PSA, prostate-specific antigen. Notes. 1. Strategy 1: MRI targeted biopsy. Strategy 4: MRI targeted biopsy ➔ Systematic biopsy ➔ Saturation biopsy. 2. MRI targeted biopsy refers to the administration of MRI targeted biopsy combined with systematic biopsy following a positive mpMRI. 3. Blue bars denote the ICERs when the parameter’s lower bound limit is tested; red bars denote the ICERs when the parameter’s upper bound limit is tested.