Cost-effectiveness plane of base case analyses. Abbreviations: mpMRI, multiparametric magnetic resonance imaging; MRI, magnetic resonance imaging; QALY, quality-adjusted life years; USD, US dollars. Notes. 1. Strategy 1: MRI targeted biopsy. Strategy 2: MRI targeted biopsy ➔ Systematic biopsy. Strategy 3: MRI targeted biopsy ➔ Saturation biopsy. Strategy 4: MRI targeted biopsy ➔ Systematic biopsy ➔ Saturation biopsy. Strategy 5: Systematic biopsy ➔ MRI targeted biopsy. Strategy 6: Systematic biopsy ➔ MRI targeted biopsy ➔ Saturation biopsy. 2. MRI targeted biopsy refers to the administration of MRI targeted biopsy combined with systematic biopsy following a positive mpMRI. 3. Strategies 1, 2, 4 are on the cost-effectiveness frontier, indicating that they achieve the most QALY per USD spent; Strategies 3, 5, 6 are dominated as they are more costly and gave fewer QALYs.