Simplified schema of model structure. Abbreviations: CRPC, castration-resistant prostate cancer; mpMRI, multiparametric magnetic resonance imaging; PI-RADS, Prostate Imaging – Reporting and Data System scores. Notes. 1. MRI targeted biopsy refers to the administration of MRI targeted biopsy combined with systematic biopsy following a positive mpMRI. 2. Diagnostic tests used only in repeat biopsy settings (i.e. as second or third biopsy) are represented in dotted lines.