Table 3 Measurement domains, survey methods and collection time-points
Variable | Component | Measurement methods | Baseline | 3rd M | 6th M | 9th M | 12th M |
|---|---|---|---|---|---|---|---|
Socio-demographic parameters | Gender, age, telephone, address, education, occupation and annual income | Face-to-face interview | √ | ||||
Clinical parameters | Height, weight, warfarin indication, start date of warfarin, warfarin dosage, TTR calculated by INR tests in the preceding 12 months, history of thrombosis or major bleeding, concomitant diseases and medicine Warfarin dosage, INR, bleeding or thrombosis, other clinical adverse events | Face-to-face interview | √ | ||||
Face-to-face interview, telephone or online interview | √ | √ | √ | √ | |||
Behaviour parameters | Anticoagulant compliance, warfarin knowledge, | Morisky Anticoagulant Compliance Questionnaire [14], Oral Anticoagulation Knowledge (OAK) Test [15] | √ | √ | |||
Treatment behavior, quality of life | Self-made questionnaire, EQ-5D-3L Form [16] | √ | √ | √ | √ | √ | |
Anticoagulation satisfaction | Duke Anticoagulation Satisfaction Scale [17] | √ | |||||
Economic parameters | Direct costs (INR test fees, outpatient clinic visit fees, hospitalization or emergency room visit fees if occurs), Indirect costs (deducted income due to absence of working, traffic and accommodation fees) | Face-to-face interview, telephone or online interview | √ | √ | √ | √ | √ |