Physical therapy first
|
Knee radiograph
|
0.13 (0.12, 0.15)
|
0.09 (0.06, 0.14)
|
Advanced imaging
|
0.37 (0.33, 0.41)
|
0.31 (0.20, 0.46)
|
Opioids
|
0.35 (0.30, 0.42)
|
0.33 (0.18, 0.59)
|
Muscle relaxants
|
0.37 (0.29, 0.48)
|
0.37 (0.16, 0.76)
|
NSAIDs
|
0.33 (0.28, 0.38)
|
0.30 (0.16, 0.52)
|
Other analgesics (acetaminophen, etc.)
|
0.38 (0.29, 0.49)
|
0.32 (0.13, 0.69)
|
Corticosteroid injections
|
0.37 (0.30, 0.45)
|
0.26 (0.10, 0.55)
|
Early physical therapy
|
Knee radiograph
|
0.59 (0.55, 0.65)
|
0.48 (0.34, 0.66)
|
Advanced imaging
|
0.53 (0.49, 0.57)
|
0.49 (0.37, 0.65)
|
Opioids
|
0.68 (0.60, 0.76)
|
0.53 (0.37, 0.75)
|
Muscle relaxants
|
0.80 (0.68, 0.94)
|
0.61 (0.39, 0.96)
|
NSAIDs
|
0.73 (0.66, 0.81)
|
0.58 (0.42, 0.81)
|
Other analgesics (acetaminophen, etc.)
|
0.73 (0.61, 0.87)
|
0.52 (0.32, 0.83)
|
Corticosteroid injections
|
0.68 (0.59, 0.78)
|
0.46 (0.29, 0.62)
|
Delayed physical therapy
|
Knee radiograph
|
1.68 (1.55, 1.83)
|
2.11 (1.53, 2.94)
|
Advanced imaging
|
1.90 (1.75, 2.05)
|
2.03 (1.54, 2.68)
|
Opioids
|
1.48 (1.32, 1.66)
|
1.90 (1.33, 2.70)
|
Muscle relaxants
|
1.25 (1.07, 1.47)
|
1.64 (1.04, 2.58)
|
NSAIDs
|
1.37 (1.24, 1.51)
|
1.73 (1.23, 2.41)
|
Other analgesics (acetaminophen, etc.)
|
1.36 (1.15, 1.62)
|
1.94 (1.21, 3.10)
|
Corticosteroid injections
|
1.48 (1.29, 1.70)
|
2.20 (1.40, 3.46)
|
No physical therapy
|
Knee radiograph
|
0.61 (0.59, 0.64)
|
0.52 (0.47, 0.61)
|
Advanced imaging
|
0.55 (0.53, 0.47)
|
0.55 (0.48, 0.63)
|
Opioids
|
0.55 (0.52, 0.59)
|
0.55 (0.45, 0.67)
|
Muscle relaxants
|
0.57 (0.52, 0.62)
|
0.52 (0.41, 0.67)
|
NSAIDs
|
0.53 (0.50, 0.55)
|
0.54 (0.45, 0.65)
|
Other analgesics (acetaminophen, etc.)
|
0.54 (0.49, 0.60)
|
0.53 (0.41, 0.69)
|
Corticosteroid injections
|
0.57 (0.53, 0.62)
|
0.56 (0.43, 0.72)
|
Exercise therapy
|
Knee radiograph
|
0.37 (0.34, 0.40)
|
0.30 (0.22, 0.40)
|
Advanced imaging
|
0.47 (0.44, 0.51)
|
0.48 (0.37, 0.62)
|
Opioids
|
0.59 (0.53, 0.66)
|
0.55 (0.39, 0.78)
|
Muscle relaxants
|
0.65 (0.56, 0.76)
|
0.52 (0.34, 0.82)
|
NSAIDs
|
0.62 (0.56, 0.68)
|
0.58 (0.42, 0.81)
|
Other analgesics (acetaminophen, etc.)
|
0.62 (0.53, 0.74)
|
0.53 (0.34, 0.84)
|
Corticosteroid injections
|
0.58 (0.51, 0.66)
|
0.40 (0.26, 0.61)
|
Passive interventions only
|
Knee radiograph
|
0.37 (0.29, 0.47)
|
0.42 (0.17, 1.01)
|
Advanced imaging
|
0.46 (0.37, 0.58)
|
0.82 (0.36, 1.87)
|
Opioids
|
0.69 (0.50, 0.96)
|
0.57 (0.21, 1.55)
|
Muscle relaxants
|
0.69 (0.45, 1.08)
|
1.02 (0.32, 3.52)
|
NSAIDs
|
0.67 (0.50, 0.89)
|
0.69 (0.26, 1.81)
|
Other analgesics (acetaminophen, etc.)
|
0.72 (0.44, 1.18)
|
0.56 (0.15, 2.05)
|
Corticosteroid injections
|
0.35 (0.24, 0.51)
|
0.53 (0.12, 2.15)
|