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Table 4 Results of the cost-effectiveness analyses: HypoAware study

From: The statistical approach in trial-based economic evaluations matters: get your statistics together!

Analysis Societal costs difference (€) (95% CI) QALY difference (95% CI) ICER (€/ QALY gained)
1.- Two t-tests (1 for cost; 1 for effects) complete-case analysis −142 (− 1298 to 1014) −0.002 (− 0.057 to 0.54) 90,989
2.- Two bootstrapped t-tests; complete-case analysis −142 (− 1326 to 986) − 0.002 (− 0.057 to 0.54) 90,989
3.- Two regressions with correction for confounders; complete-case analysis −23 (− 1180 to 1134) −0.009 (− 0.041 to 0.03) 2536
4.- Two bootstrapped regressions with correction for confounders; complete-case analysis −23 (− 1170 to 1096) −0.009 (− 0.041 to 0.03) 2536
5.- Two t-tests; mean imputation − 105 (− 971 to 759) 0.006 (− 0.037 to 0.049) − 17,307
6.- Two bootstrapped t-tests; mean imputation − 105 (− 1032 to 739) 0.006 (− 0.037 to 0.049) −17,307
7.- Two regressions with correction for confounders; mean imputation −85 (− 954 to 784) 0.009 (− 0.020 to 0.038) − 9208
8.- Two bootstrapped regressions with correction for confounders; mean imputation −85 (− 966 to 770) 0.009 (− 0.020 to 0.038) − 9208
9.- Two t-tests; MI 438 (− 1033 to 1910) 0.006 (− 0.041 to 0.053) 74,862
10.- Two bootstrapped t-tests; MI 438 (− 940 to 1704) 0.006 (− 0.041 to 0.053) 74,862
11.- Two regressions with correction for confounders; MI 486 (− 995 to 1968) 0.010 (− 0.022 to 0.042) 47,305
12.- Two bootstrapped regressions with correction for confounders; MI 486 (− 904 to 1747) 0.010 (− 0.022 to 0.042) 47,305
13.- SUR without correction for confounders; MI 438 (− 936 to 1712) 0.006 (− 0.042 to 0.053) 74,862
14.- SUR with correction for confounders; MI 462 (− 921 to 1728) 0.010 (− 0.022 to 0.0423) 46,592
  1. 95% CI 95% Confidence Interval, ICER Incremental Cost-Effectiveness Ratio, MI Multiple Imputation, SUR Seemingly Unrelated Regression, QALY Quality Adjusted Life-year