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Table 1 Description of studies retained by the literature review

From: Effect of burnout among physicians on observed adverse patient outcomes: a literature review

Study

Country

Design

Sample

N

Response rate

Measured dimensions of burnout

Observed measure on quality of care

Association with burnout

Fahrenkopf et al. 2008 [22]

USA

Observational prospective cohort study

Paediatric residents

246

50%

EE and DPa

Missing or wrong prescription of drugs

Not associated with adverse patient treatment

Zantinge et al. 2009 [23]

Netherlands

Observation of video-recorded consultations and questionnaire

GPs

142

89%

EE, DP and PAb

Length of consultations, level of verbal communication, eye contact, and focus on psychosocial issues

PA associated with GPs communicating less affectively, being less patient-centred and less eye contact. EE and DP not associated with adverse patient treatment

Kushnir et al. 2014 [24]

Israel

Cross-sectional observational study

GPs/Primary care

136

99%

EE, DP and PAc

Number of referrals for diagnostic imaging, specialized health services or nurse sensitive treatments

Associated with more referrals

Yuguero Torres et al. 2015 [25]

Spain

Prospective observational study (1 year)

GPs

217

50%

EE, DP and PAd

Number of prescribed sick leaves

Not associated with prescribing more or longer sick leaves

Garrouste-Orgeas et al. 2015 [26]

France

Prospective observational study (2-year)

Doctors, nurses and care workers in intensive care unit

1988 (330 doctors)

77%

EE, DP and PAe

Medical errors (i.e., error of execution or error of planning). Adverse events were patient harms caused by medical interventions.

Not associated with adverse patient treatment

Welp et al. 2015 [19]

Switzerland

Observational study

Doctors and nurses in intensive care unit

1425 (243 doctors)

Not specified

EE, DP and PAf

Length of stay in hospital and standardized mortality ratio

Associated with increased standardized mortality ratio, but not length of stay

Pedersen et al. 2015 [27]

Denmark

Register study and questionnaire

GPs

835

72%

EE, DP and PAg

Number of requisitions for PSA among healthy male patients

Not associated with increased requisitions for PSA

Kwah et al. 2016 [28]

USA

Prospective observational study (1 year)

First-year residents in internal medicine

54

98% (initial), 59% (cohort)

EE and DPh

Medication prescription errors with potential for adverse drug effects

Not associated with increase in medical errors

Sun et al. 2017 [29]

USA

Cross-sectional observational study

Primary care

102

Not specified

EE, DP and PAf

Antibiotic prescriptions for acute respiratory infections

Not associated with increase in prescriptions

Noroxe et al. 2019 [20]

Denmark

Prospective observational study (6 months)

GPs

781

50.2%

EE, DP and PAi

Conditions not requiring hospitalization in the case of appropriate intervention in primary care (ambulatory care sensitive conditions)

Associated with increased frequency of hospitalizations of ambulatory care sensitive conditions

Noroxe et al. 2019 [21]

Denmark

Prospective observational study (6 months)

GPs

409

50.2%

EE, DP and PAi

Change of GP (unrelated to change of address)

Associated with increased likelihood of changing GPs

  1. Abbreviations: EE emotional exhaustion, DP depersonalization, PA personal accomplishment (reduced), GP general practitioner, PSA prostate-specific antigen, MBI Maslach Burnout Inventory
  2. aDefined burnout as EE > 27 and DP > 10
  3. bEE, DP and PA were dichotomized into low and high scores, and outcomes reported for each dimension
  4. cOverall burnout was measured as an average of the responses to items EE and DP (continuous variable)
  5. dScores for each category were divided into low, moderate and high
  6. eBurnout measured as
  7. (1) a combination of high EE and DP with low PA (dimensions dichotomized), and
  8. (2) defined as over a cut-off of a global MBI score of 9
  9. fEach dimension used as a continuous variable
  10. gBurnout defined as high level of emotional exhaustion > 26
  11. hBurnout defined as a high EE or high DP subscore (dichotomized variables)
  12. iBurnout measured
  13. 1) in four quartiles for each dimension
  14. 2) As a composite score by adding up points corresponding to the quartile of each subscale (reversed score for personal accomplishment);
  15. one point for scores in the first quartile, and two, three and four points for subsequent quartiles, respectively. The composite score was categorized into five groups, with increasing score indicating higher burnout