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Table 3 Accuracy of Electronic Prescribing Data and Diagnostic Codes in Administrative Health Data in Detecting Adverse Drug Events, Overall and by Medication Class

From: Detection of adverse drug events in e-prescribing and administrative health data: a validation study

Data Source Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
All Patients
 Electronic Prescribing Data 9.7% (4.9–16.6%) 95.0% (92.8–96.6%) 27.5% (14.6–43.9%) 84.1% (81.1–86.8%)
 Adminsitrative Health Dataa 7.0% (3.1–13.4%) 90.6% (87.9–92.9%) 12.9% (5.7–23.9%) 83.1% (79.9–85.9%)
 Electronic Prescribing & Administrative Health Dataa 14.0% (8.2–21.8%) 86.1% (83.0–88.8%) 16.7% (9.8–25.7%) 83.5% (80.2–86.4%)
Patients Prescribed an Antidepressant
 Electronic Prescribing Data 13.5% (6.7–23.5%) 95.6% (92.1–97.9%) 50.0% (27.2–72.8%) 77.3% (72.0–82.1%)
 Adminsitrative Health Dataa 5.4% (1.5–13.3%) 94.7% (93.8–98.8%) 36.4% (10.9–69.2%) 76.0% (71.0–80.9%)
 Electronic Prescribing & Administrative Health Dataa 16.2% (8.7–26.6%) 92.5% (88.3–95.6%) 41.4% (23.5–61.1%) 77.3% (71.9–82.1%)
Patients Prescribed an Antihypertensive
 Electronic Prescribing Data 2.5% (0.0–13.2%) 94.5% (91.6–96.7%) 5.0% (0.1–24.9%) 89.3% (85.7–92.3%)
 Adminsitrative Health Dataa 10.0% (2.8–23.7%) 86.4% (82.3–89.9%) 7.8% (2.2–18.9%) 89.3% (85.4–92.4%)
 Electronic Prescribing & Administrative Health Dataa 10.0% (2.8–23.7%) 81.8% (77.3–85.7%) 6.0% (1.7–14.6%) 88.7% (84.7–92.0%)
  1. Abbreviations: CI Confidence interval, PPV positive predictive value, NPV negative predictive value
  2. aResults are presented for the expanded ICD code set